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http://purl.uniprot.org/citations/28375947http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objectives

Pancreatic intraepithelial neoplasia lesions can appear as chronic pancreatitis-like changes on endoscopic ultrasound (EUS). The aim of our study was to determine if BRCA2 mutation carriers were more likely than noncarriers to demonstrate chronic pancreatitis-like changes on EUS.

Methods

Patients with BRCA2 mutations referred for EUS were identified (cases) from an endoscopy database. Controls were matched with cases in a 2:1 ratio for sex, date EUS was performed, endoscopist, and echoendoscope. Data were extracted from medical records, EUS reports, and EUS images. Rosemont classification was used to categorize chronic pancreatitis-like changes.

Results

During the study period, 37 BRCA2 mutation carriers and 92 controls underwent EUS. Compared with controls, BRCA2 mutation carriers had a higher prevalence of solid pancreas lesions (16.2% vs 1.08%; P = 0.005), pancreatic cysts (21.6% vs 6.1%; P = 0.01), Rosemont "consistent with chronic pancreatitis" definition changes (13.5% vs 1%; P = 0.002), and Rosemont "suggestive of chronic pancreatitis" definition changes (16.2% vs 2.1%; P = 0.003). After adjusting for age, alcohol use, and smoking, BRCA2 mutation carriers were almost 25 times more likely to demonstrate chronic pancreatitis-like changes.

Conclusions

Chronic pancreatitis-like changes, along with solid and cystic pancreatic lesions, were significantly more common in BRCA2 mutation carriers than in noncarriers."xsd:string
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http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/author"Wong D."xsd:string
http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/author"Mizrahi M."xsd:string
http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/author"Tung N."xsd:string
http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/author"Berzin T.M."xsd:string
http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/author"Eskander M.F."xsd:string
http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/author"Pleskow D.K."xsd:string
http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/author"Sawhney M.S."xsd:string
http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/author"Tseng J.F."xsd:string
http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/name"Pancreas"xsd:string
http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/pages"679-683"xsd:string
http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/title"Chronic Pancreatitis-Like Change in BRCA2 Mutation Carriers."xsd:string
http://purl.uniprot.org/citations/28375947http://purl.uniprot.org/core/volume"46"xsd:string
http://purl.uniprot.org/citations/28375947http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28375947
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