| http://purl.uniprot.org/citations/28380351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28380351 | http://www.w3.org/2000/01/rdf-schema#comment | "Many pathogens initiate infection at mucosal surfaces, and tissue-resident memory T (Trm) cells play an important role in protective immunity, yet the tissue-specific signals that regulate Trm differentiation are poorly defined. During Yersinia infection, CD8+ T cell recruitment to areas of inflammation within the intestine is required for differentiation of the CD103-CD69+ Trm subset. Intestinal proinflammatory microenvironments have elevated interferon (IFN)-β and interleukin-12 (IL-12), which regulated Trm markers, including CD103. Type I interferon-receptor- or IL-12-receptor-deficient T cells functioned similarly to wild-type (WT) cells during infection; however, the inability of T cells to respond to inflammation resulted in defective differentiation of CD103-CD69+ Trm cells and reduced Trm persistence. Intestinal macrophages were the main producers of IFN-β and IL-12 during infection, and deletion of CCR2+ IL-12-producing cells reduced the size of the CD103- Trm population. These data indicate that intestinal inflammation drives phenotypic diversity and abundance of Trm cells for optimal tissue-specific immunity."xsd:string |
| http://purl.uniprot.org/citations/28380351 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.03.031"xsd:string |
| http://purl.uniprot.org/citations/28380351 | http://purl.uniprot.org/core/author | "Fink P.J."xsd:string |
| http://purl.uniprot.org/citations/28380351 | http://purl.uniprot.org/core/author | "Bevan M.J."xsd:string |
| http://purl.uniprot.org/citations/28380351 | http://purl.uniprot.org/core/author | "Bergsbaken T."xsd:string |
| http://purl.uniprot.org/citations/28380351 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28380351 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/28380351 | http://purl.uniprot.org/core/pages | "114-124"xsd:string |
| http://purl.uniprot.org/citations/28380351 | http://purl.uniprot.org/core/title | "Local Inflammatory Cues Regulate Differentiation and Persistence of CD8+ Tissue-Resident Memory T Cells."xsd:string |
| http://purl.uniprot.org/citations/28380351 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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