| http://purl.uniprot.org/citations/28380354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28380354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28380354 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila hnRNP F/H homolog, Glorund (Glo), regulates nanos mRNA translation by interacting with a structured UA-rich motif in the nanos 3' untranslated region. Glo regulates additional RNAs, however, and mammalian homologs bind G-tract sequences to regulate alternative splicing, suggesting that Glo also recognizes G-tract RNA. To gain insight into how Glo recognizes both structured UA-rich and G-tract RNAs, we used mutational analysis guided by crystal structures of Glo's RNA-binding domains and identified two discrete RNA-binding surfaces that allow Glo to recognize both RNA motifs. By engineering Glo variants that favor a single RNA-binding mode, we show that a subset of Glo's functions in vivo is mediated solely by the G-tract binding mode, whereas regulation of nanos requires both recognition modes. Our findings suggest a molecular mechanism for the evolution of dual RNA motif recognition in Glo that may be applied to understanding the functional diversity of other RNA-binding proteins."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.03.022"xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.03.022"xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/author | "Chatterjee S."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/author | "Chatterjee S."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/author | "Teramoto T."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/author | "Teramoto T."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/author | "Gavis E.R."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/author | "Gavis E.R."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/author | "Tamayo J.V."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/author | "Tamayo J.V."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/author | "Hall T.M.T."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/author | "Hall T.M."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/pages | "150-161"xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/pages | "150-161"xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/title | "The Drosophila hnRNP F/H Homolog Glorund Uses Two Distinct RNA-Binding Modes to Diversify Target Recognition."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/title | "The Drosophila hnRNP F/H Homolog Glorund Uses Two Distinct RNA-Binding Modes to Diversify Target Recognition."xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/28380354 | http://purl.uniprot.org/core/volume | "19"xsd:string |