| http://purl.uniprot.org/citations/28380378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28380378 | http://www.w3.org/2000/01/rdf-schema#comment | "In cells experiencing unrelieved endoplasmic reticulum (ER) stress, the ER transmembrane kinase/endoribonuclease (RNase)-IRE1α-endonucleolytically degrades ER-localized mRNAs to promote apoptosis. Here we find that the ABL family of tyrosine kinases rheostatically enhances IRE1α's enzymatic activities, thereby potentiating ER stress-induced apoptosis. During ER stress, cytosolic ABL kinases localize to the ER membrane, where they bind, scaffold, and hyperactivate IRE1α's RNase. Imatinib-an anti-cancer tyrosine kinase inhibitor-antagonizes the ABL-IRE1α interaction, blunts IRE1α RNase hyperactivity, reduces pancreatic β cell apoptosis, and reverses type 1 diabetes (T1D) in the non-obese diabetic (NOD) mouse model. A mono-selective kinase inhibitor that allosterically attenuates IRE1α's RNase-KIRA8-also efficaciously reverses established diabetes in NOD mice by sparing β cells and preserving their physiological function. Our data support a model wherein ER-stressed β cells contribute to their own demise during T1D pathogenesis and implicate the ABL-IRE1α axis as a drug target for the treatment of an autoimmune disease."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2017.03.018"xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Ghosh R."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Maly D.J."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Morita S."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Rosenthal W."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Papa F.R."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Bluestone J.A."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Mehdizadeh M."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Villalta S.A."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Backes B.J."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Hoffmann-Petersen I.T."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Feldman H.C."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Meza-Acevedo R."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Colon-Negron K."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/author | "Register A.C."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/pages | "883-897.e8"xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/title | "Targeting ABL-IRE1alpha Signaling Spares ER-Stressed Pancreatic beta Cells to Reverse Autoimmune Diabetes."xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/28380378 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28380378 |
| http://purl.uniprot.org/citations/28380378 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28380378 |