| http://purl.uniprot.org/citations/28381482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28381482 | http://www.w3.org/2000/01/rdf-schema#comment | "The amplitude of transforming growth factor-β (TGF-β) signal is tightly regulated to ensure appropriate physiological responses. As part of negative feedback loop SMAD7, a direct transcriptional target of downstream TGF-β signaling acts as a scaffold to recruit the E3 ligase SMURF2 to target the TGF-β receptor complex for ubiquitin-mediated degradation. Here, we identify the deubiquitinating enzyme USP26 as a novel integral component of this negative feedback loop. We demonstrate that TGF-β rapidly enhances the expression of USP26 and reinforces SMAD7 stability by limiting the ubiquitin-mediated turnover of SMAD7. Conversely, knockdown of USP26 rapidly degrades SMAD7 resulting in TGF-β receptor stabilization and enhanced levels of p-SMAD2. Clinically, loss of USP26 correlates with high TGF-β activity and confers poor prognosis in glioblastoma. Our data identify USP26 as a novel negative regulator of the TGF-β pathway and suggest that loss of USP26 expression may be an important factor in glioblastoma pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.201643270"xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://purl.uniprot.org/core/author | "Pang B."xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://purl.uniprot.org/core/author | "Eichhorn P.J.A."xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://purl.uniprot.org/core/author | "Jaynes P."xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://purl.uniprot.org/core/author | "Kit Leng Lui S."xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://purl.uniprot.org/core/author | "Iyengar P.V."xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://purl.uniprot.org/core/author | "Tan T.Z."xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://purl.uniprot.org/core/author | "Isa Z.F.B.A."xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28381482 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://purl.uniprot.org/core/pages | "797-808"xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://purl.uniprot.org/core/title | "USP26 regulates TGF-beta signaling by deubiquitinating and stabilizing SMAD7."xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/28381482 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28381482 |
| http://purl.uniprot.org/citations/28381482 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28381482 |
| http://purl.uniprot.org/uniprot/#_B3KYA8-mappedCitation-28381482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28381482 |
| http://purl.uniprot.org/uniprot/#_O15105-mappedCitation-28381482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28381482 |
| http://purl.uniprot.org/uniprot/B3KYA8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28381482 |
| http://purl.uniprot.org/uniprot/O15105 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28381482 |