| http://purl.uniprot.org/citations/28390194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28390194 | http://www.w3.org/2000/01/rdf-schema#comment | "Aging is associated with significant changes in hematopoiesis, including clonal dominance, anemia, myeloid malignancies, and reduced activation of signal transducer and activator of transcription 5 (Stat5). In previous studies, Stat5 deletion surprisingly amplified FLT3/ITD+ myeloid expansion or Myc-driven lymphoid expansion. Here we show that Stat5 deficiency has a strong impact upon transcriptional heterogeneity in single sorted c-Kit+Lin-Sca-1+ (KLS) cells or CD150+CD48-KLS long-term repopulating hematopoietic stem cells (LT-HSC). Single cell polymerase chain reaction (PCR) was performed on selected regulators of multi-lineage hematopoiesis. At least two dominant sub-populations were identified by increased expression of cell cycle regulatory and leukemia-associated genes. Furthermore, in the top expressing quartile of cells, the majority of genes were proportionally overrepresented. In wild-type KLS cells, Stat5 mRNA levels were also strongly correlated with several genes. Since heterogeneity decreases with age or inflammatory or oncogenic stress, these results provide a potential mechanistic linkage to Stat5 expression."xsd:string |
| http://purl.uniprot.org/citations/28390194 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.15236"xsd:string |
| http://purl.uniprot.org/citations/28390194 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/28390194 | http://purl.uniprot.org/core/author | "Bunting K.D."xsd:string |
| http://purl.uniprot.org/citations/28390194 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28390194 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/28390194 | http://purl.uniprot.org/core/pages | "22477-22482"xsd:string |
| http://purl.uniprot.org/citations/28390194 | http://purl.uniprot.org/core/title | "Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations."xsd:string |
| http://purl.uniprot.org/citations/28390194 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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