| http://purl.uniprot.org/citations/28391641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28391641 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila RNA-binding protein Sex-lethal (Sxl) is a potent post-transcriptional regulator of gene expression that controls female development. It regulates the expression of key factors involved in sex-specific differences in morphology, behavior, and dosage compensation. Functional Sxl protein is only expressed in female flies, where it binds to U-rich RNA motifs present in its target mRNAs to regulate their fate. Sxl is a very versatile regulator that, by shuttling between the nucleus and the cytoplasm, can regulate almost all aspects of post-transcriptional gene expression including RNA processing, nuclear export, and translation. For these functions, Sxl employs multiple interactions to either antagonize RNA-processing factors or to recruit various coregulators, thus allowing it to establish a female-specific gene expression pattern. Here, we summarize the current knowledge about Sxl function and review recent mechanistic and structural studies that further our understanding of how such a seemingly 'simple' RNA-binding protein can exert this plethora of different functions."xsd:string |
| http://purl.uniprot.org/citations/28391641 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.12652"xsd:string |
| http://purl.uniprot.org/citations/28391641 | http://purl.uniprot.org/core/author | "Gaik M."xsd:string |
| http://purl.uniprot.org/citations/28391641 | http://purl.uniprot.org/core/author | "Medenbach J."xsd:string |
| http://purl.uniprot.org/citations/28391641 | http://purl.uniprot.org/core/author | "Moschall R."xsd:string |
| http://purl.uniprot.org/citations/28391641 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28391641 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/28391641 | http://purl.uniprot.org/core/pages | "1471-1488"xsd:string |
| http://purl.uniprot.org/citations/28391641 | http://purl.uniprot.org/core/title | "Promiscuity in post-transcriptional control of gene expression: Drosophila sex-lethal and its regulatory partnerships."xsd:string |
| http://purl.uniprot.org/citations/28391641 | http://purl.uniprot.org/core/volume | "591"xsd:string |
| http://purl.uniprot.org/citations/28391641 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28391641 |
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| http://purl.uniprot.org/uniprot/#_A4V038-mappedCitation-28391641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28391641 |
| http://purl.uniprot.org/uniprot/#_A0A4D6K5H4-mappedCitation-28391641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28391641 |
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| http://purl.uniprot.org/uniprot/#_A1YJT1-mappedCitation-28391641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28391641 |