| http://purl.uniprot.org/citations/28396589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28396589 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucose-stimulated insulin secretion (GSIS) is essential in keeping blood glucose levels within normal range. GSIS is impaired in type 2 diabetes, and its recovery is crucial in treatment of the disease. We find here that sphingosine kinase 1-interacting protein (SKIP, also called Sphkap) is highly expressed in pancreatic β-cells but not in α-cells. Intraperitoneal glucose tolerance test showed that plasma glucose levels were decreased and insulin levels were increased in SKIP-/- mice compared to SKIP+/+ mice, but exendin-4-enhanced insulin secretion was masked. GSIS was amplified more in SKIP-/- but exendin-4-enhanced insulin secretion was masked compared to that in SKIP+/+ islets. The ATP and cAMP content were similarly increased in SKIP+/+ and SKIP-/- islets; depolarization-evoked, PKA and cAMP-mediated insulin secretion were not affected. Inhibition of PDE activity equally augmented GSIS in SKIP+/+ and SKIP-/- islets. These results indicate that SKIP modulates GSIS by a pathway distinct from that of cAMP-, PDE- and sphingosine kinase-dependent pathways."xsd:string |
| http://purl.uniprot.org/citations/28396589 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-00900-7"xsd:string |
| http://purl.uniprot.org/citations/28396589 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/28396589 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28396589 | http://purl.uniprot.org/core/author | "Inagaki N."xsd:string |
| http://purl.uniprot.org/citations/28396589 | http://purl.uniprot.org/core/author | "Usui R."xsd:string |
| http://purl.uniprot.org/citations/28396589 | http://purl.uniprot.org/core/author | "Harashima S.I."xsd:string |
| http://purl.uniprot.org/citations/28396589 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28396589 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28396589 | http://purl.uniprot.org/core/pages | "779"xsd:string |
| http://purl.uniprot.org/citations/28396589 | http://purl.uniprot.org/core/title | "Sphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion."xsd:string |
| http://purl.uniprot.org/citations/28396589 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28396589 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28396589 |
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| http://purl.uniprot.org/uniprot/#_A0A0R4J1Y6-mappedCitation-28396589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28396589 |
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| http://purl.uniprot.org/uniprot/#_Q9CTQ1-mappedCitation-28396589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28396589 |
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