| http://purl.uniprot.org/citations/28401953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28401953 | http://www.w3.org/2000/01/rdf-schema#comment | "Heparanase is an endo-glucuronidase that degrades heparan sulfate chains. The enzyme is expressed at a low level in normal organs; however, elevated expression of heparanase has been detected in several inflammatory conditions, e.g. in the synovial joints of rheumatoid arthritis (RA) patients. Herein, we have applied the model of collagen-induced arthritis (CIA) to transgenic mice overexpressing human heparanase (Hpa-tg) along with wildtype (WT) mice. About 50% of the induced animals developed clinical symptoms, i.e. swelling of joints, and there were no differences between the Hpa-tg and WT mice in the incidence of disease. However, Hpa-tg mice displayed an earlier response and developed more severe symptoms. Examination of cells from thymus, spleen and lymph nodes revealed increased innate and adaptive immune responses of the Hpa-tg mice, reflected by increased proportions of macrophages, antigen presenting cells and plasmacytoid dendritic cells as well as Helios-positive CD4+ and CD8+ T cells. Furthermore, splenic lymphocytes from Hpa-tg mice showed higher proliferation activity. Our results suggest that elevated expression of heparanase augmented both the innate and adaptive immune system and propagated inflammatory reactions in the murine RA model."xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep46229"xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://purl.uniprot.org/core/author | "Singh K."xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://purl.uniprot.org/core/author | "Vlodavsky I."xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://purl.uniprot.org/core/author | "Li J.P."xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://purl.uniprot.org/core/author | "Abrink M."xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://purl.uniprot.org/core/author | "Reijmers R.M."xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://purl.uniprot.org/core/author | "Sandler S."xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://purl.uniprot.org/core/author | "Digre A."xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28401953 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://purl.uniprot.org/core/pages | "46229"xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://purl.uniprot.org/core/title | "Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis."xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28401953 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28401953 |
| http://purl.uniprot.org/citations/28401953 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28401953 |
| http://purl.uniprot.org/uniprot/#_D3Z3C3-mappedCitation-28401953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28401953 |
| http://purl.uniprot.org/uniprot/#_Q6YGZ1-mappedCitation-28401953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28401953 |
| http://purl.uniprot.org/uniprot/Q6YGZ1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28401953 |
| http://purl.uniprot.org/uniprot/D3Z3C3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28401953 |