| http://purl.uniprot.org/citations/28402964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28402964 | http://www.w3.org/2000/01/rdf-schema#comment | "Trichloroethylene (TCE) is an occupational and environmental chemical that can cause severe hepatotoxicity. While our previous studies showed that the phosphatase inhibitor SET is a key mediator of TCE-induced liver cell apoptosis, the molecular mechanisms remain elusive. Using quantitative phosphoproteomic analysis, we report here that nucleolin is a SET-regulated phosphoprotein in human liver HL-7702 cells. Functional analysis suggested that SET promoted dephosphorylation of nucleolin, decreased its binding to its transcriptional activator, c-myc, and upregulated nucleolin expression in TCE-treated cells. Importantly, TCE-induced hepatocyte apoptosis was significantly attenuated when nucleolin was downregulated with specific siRNAs. These findings indicate that TCE may induce hepatocyte apoptosis via SET-mediated dephosphorylation and overexpression of nucleolin."xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.16785"xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/author | "Ren X."xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/author | "Zou F."xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/pages | "40958-40966"xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/title | "SET mediates TCE-induced liver cell apoptosis through dephosphorylation and upregulation of nucleolin."xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/28402964 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28402964 |
| http://purl.uniprot.org/citations/28402964 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28402964 |
| http://purl.uniprot.org/uniprot/#_A0A8J8YYJ1-mappedCitation-28402964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28402964 |
| http://purl.uniprot.org/uniprot/#_B2RCX0-mappedCitation-28402964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28402964 |
| http://purl.uniprot.org/uniprot/#_Q5VXV3-mappedCitation-28402964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28402964 |
| http://purl.uniprot.org/uniprot/#_Q01105-mappedCitation-28402964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28402964 |
| http://purl.uniprot.org/uniprot/A0A8J8YYJ1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28402964 |
| http://purl.uniprot.org/uniprot/Q01105 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28402964 |