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Objectives

Ankylosing spondylitis (AS) is a chronic inflammatory joint disease. The transporter associated with antigen processing (TAP) has been identified to play an important role in immune response as well as the HLA-associated diseases. The aim of our meta-analysis was to investigate the contribution of TAP (TAP1 and TAP2) polymorphisms to the risk of AS.

Methods

Meta-analyses were performed between 2 polymorphisms in TAP1 (TAP1-333, -637) and 3 polymorphisms in TAP2 (TAP2-379, -565, and -665) and AS.

Results

The meta-analyses were involved with 6 studies with 415 cases and 659 controls. Significant association was found between TAP1-333Val, TAP1-637Gly, and TAP2-565Thr and AS compared with combined control group (TAP1-333Val: p = 0.009, OR = 1.40, 95% CI 1.09-1.80; TAP1-637Gly: p = 0.002, OR = 1.48, 95% CI 1.15-1.91; p = 0.03, OR = 1.38, 95% CI 1.04-1.84). Subgroup analysis shown that significant association was only found in AS when compared with HLA-B27-negative controls (TAP1-333Val: p = 0.004, OR = 1.53, 95% CI 1.14-2.06; TAP1-637Gly: p = 0.004, OR = 1.52, 95% CI 1.15-2.02; p = 0.02, OR = 1.56, 95% CI 1.09-2.24), but not in AS when compared with HLA-B27-positive controls (p > 0.05). Moreover, no significant associations were found between haplotypes in TAP1 and TAP2 in both the combined and the subgroup analyses (p > 0.05).

Conclusions

TAP1-333Val, TAP1-637Gly, and TAP2-565Thr were likely to be associated with AS."xsd:string
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http://purl.uniprot.org/citations/28405734http://purl.uniprot.org/core/author"Chen L."xsd:string
http://purl.uniprot.org/citations/28405734http://purl.uniprot.org/core/author"Qian Y."xsd:string
http://purl.uniprot.org/citations/28405734http://purl.uniprot.org/core/author"Tang L."xsd:string
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http://purl.uniprot.org/citations/28405734http://purl.uniprot.org/core/author"Wang G."xsd:string
http://purl.uniprot.org/citations/28405734http://purl.uniprot.org/core/author"Yang H."xsd:string
http://purl.uniprot.org/citations/28405734http://purl.uniprot.org/core/author"Xue F."xsd:string
http://purl.uniprot.org/citations/28405734http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28405734http://purl.uniprot.org/core/name"Inflamm Res"xsd:string
http://purl.uniprot.org/citations/28405734http://purl.uniprot.org/core/pages"653-661"xsd:string
http://purl.uniprot.org/citations/28405734http://purl.uniprot.org/core/title"Genetic association between TAP1 and TAP2 polymorphisms and ankylosing spondylitis: a systematic review and meta-analysis."xsd:string
http://purl.uniprot.org/citations/28405734http://purl.uniprot.org/core/volume"66"xsd:string
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