| http://purl.uniprot.org/citations/28406961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28406961 | http://www.w3.org/2000/01/rdf-schema#comment | "Cisplatin is a highly-effective and widely-used chemotherapeutic agent that causes ototoxicity in many patients. Pharmacogenomic studies of key genes controlling drug biotransformation identified variants in thiopurine methyltransferase (TPMT) as predictors of cisplatin-induced ototoxicity, although the mechanistic basis of this interaction has not been reported. Expression constructs of TPMT*3A, *3B and *3C variants were generated and monitored in cultured cells. Cellular TPMT*3A levels were detected at >20-fold lower amounts than the wild type confirming the unstable nature of this variant. The expression of wild type TPMT (TPMT*1) in two murine ear cell lines, HEI-OC1 and UB/OC-1, significantly mitigated their susceptibility to cisplatin toxicity. Cisplatin treatment induced Tlr4 gene expression in HEI-OC1 cells and this response was blunted by the expression of wild type TPMT but not TPMT*3A. In line with the significant mitigation of TPMT*1-expressing cells to cisplatin cytotoxicity, these findings demonstrate a drug-gene interaction between increased TPMT activity and decreased susceptibility to cisplatin-induced toxicity of inner ear cells."xsd:string |
| http://purl.uniprot.org/citations/28406961 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0175711"xsd:string |
| http://purl.uniprot.org/citations/28406961 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/28406961 | http://purl.uniprot.org/core/author | "Ross C.J."xsd:string |
| http://purl.uniprot.org/citations/28406961 | http://purl.uniprot.org/core/author | "Bhavsar A.P."xsd:string |
| http://purl.uniprot.org/citations/28406961 | http://purl.uniprot.org/core/author | "Carleton B.C."xsd:string |
| http://purl.uniprot.org/citations/28406961 | http://purl.uniprot.org/core/author | "Gunaretnam E.P."xsd:string |
| http://purl.uniprot.org/citations/28406961 | http://purl.uniprot.org/core/author | "Hasbullah J.S."xsd:string |
| http://purl.uniprot.org/citations/28406961 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28406961 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/28406961 | http://purl.uniprot.org/core/pages | "e0175711"xsd:string |
| http://purl.uniprot.org/citations/28406961 | http://purl.uniprot.org/core/title | "Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines."xsd:string |
| http://purl.uniprot.org/citations/28406961 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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