| http://purl.uniprot.org/citations/28408404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28408404 | http://www.w3.org/2000/01/rdf-schema#comment | "Integrin activation is an indispensable step for various integrin-mediated biological functions. Kindlin-2 is known to coactivate integrins with Talin; however, molecules that restrict integrin activation are elusive. Here, we demonstrate that the E3 ubiquitin ligase Smurf1 controls the amount of Kindlin-2 protein in cells and hinders integrin activation. Smurf1 interacts with and promotes Kindlin-2 ubiquitination and degradation. Smurf1 selectively mediates degradation of Kindlin-2 but not Talin, leading to inhibition of αIIbβ3 integrin activation in Chinese hamster ovary cells and β1 integrin activation in fibroblasts. Enhanced activation of β1 integrin was found in Smurf1-knockout mouse embryonic fibroblasts, which correlates with an increase in Kindlin-2 protein levels. Similarly, a reciprocal relationship between Smurf1 and Kindlin-2 protein levels is found in tissues from colon cancer patients, suggesting that Smurf1 mediates Kindlin-2 degradation in vivo. Collectively, we demonstrate that Smurf1 acts as a brake for integrin activation by controlling Kindlin-2 protein levels, a new mechanism that permits precise modulation of integrin-mediated cellular functions."xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201609073"xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://purl.uniprot.org/core/author | "Wei X."xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://purl.uniprot.org/core/author | "Zhan J."xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://purl.uniprot.org/core/author | "Fang W."xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28408404 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://purl.uniprot.org/core/pages | "1455-1471"xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://purl.uniprot.org/core/title | "Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation."xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://purl.uniprot.org/core/volume | "216"xsd:string |
| http://purl.uniprot.org/citations/28408404 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28408404 |
| http://purl.uniprot.org/citations/28408404 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28408404 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEN5-mappedCitation-28408404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28408404 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPQ7-mappedCitation-28408404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28408404 |
| http://purl.uniprot.org/uniprot/#_A6X940-mappedCitation-28408404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28408404 |
| http://purl.uniprot.org/uniprot/#_A6X941-mappedCitation-28408404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28408404 |
| http://purl.uniprot.org/uniprot/#_E9Q4K9-mappedCitation-28408404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28408404 |
| http://purl.uniprot.org/uniprot/#_E9PYU8-mappedCitation-28408404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28408404 |
| http://purl.uniprot.org/uniprot/#_Q3UMA4-mappedCitation-28408404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28408404 |
| http://purl.uniprot.org/uniprot/#_Q8BSC0-mappedCitation-28408404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28408404 |