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http://purl.uniprot.org/citations/28409899http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28409899http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To examine the prevalence of α1 -antitrypsin deficiency (AATD) in rheumatoid arthritis (RA), and to determine whether AATD is associated with higher levels of rheumatoid factor (RF), antinuclear antibodies (ANAs), and anti-citrullinated peptide autoantibodies (ACPAs).

Methods

RF, ANAs, and ACPAs were measured by standard immunoturbidimetry, immunofluorescence assay, and enzyme-linked immunosorbent assay, respectively. Characterization of AAT phenotypes was performed by isoelectric focusing and immunofixation. The chi-square test with Yates' correction and the Mann-Whitney U test were used to assess the prevalence of alleles associated with AATD in RA and to compare mean antibody titers, respectively.

Results

Of 246 patients with RA, 24 who were heterozygous for AATD were identified, with no statistically significant difference in the prevalence of AATD between RA patients and the general population (P = 0.39). A positive association between heterozygosity for AATD and the production of ACPAs was observed (P < 0.0001), with increased ACPA titers recorded in the AATD RA cohort compared with the general population (P = 0.01).

Conclusion

AAT heterozygous status in RA is strongly associated with positive ACPAs and may define a distinct subset of patients with increased disease severity."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.org/dc/terms/identifier"doi:10.1002/art.40127"xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"Reeves E.P."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"Carroll T.P."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"Dunne E."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"O'Connell P."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"Kenny D."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"Fearon U."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"McElvaney N.G."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"Orr C."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"McCarthy C."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"McCarthy G."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"Veale D.J."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"Dunlea D.M."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"Fee L.T."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/author"Hunt D.J.L."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/name"Arthritis Rheumatol"xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/pages"1576-1579"xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/title"Brief Report: Genetic Variation of the alphapisub>1pi/sub> -Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis."xsd:string
http://purl.uniprot.org/citations/28409899http://purl.uniprot.org/core/volume"69"xsd:string
http://purl.uniprot.org/citations/28409899http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28409899
http://purl.uniprot.org/citations/28409899http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/28409899
http://purl.uniprot.org/uniprot/#_A0A024R6N5-mappedCitation-28409899http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28409899
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