| http://purl.uniprot.org/citations/28414328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28414328 | http://www.w3.org/2000/01/rdf-schema#comment | "Splenic marginal zone B (MZB) cells, positioned at the interface between circulating blood and lymphoid tissue, detect and respond to blood-borne antigens. Here we show that MZB cells in mice activate a homeostatic program in response to a high-cholesterol diet (HCD) and regulate both the differentiation and accumulation of T follicular helper (TFH) cells. Feeding mice an HCD resulted in upregulated MZB cell surface expression of the immunoregulatory ligand PDL1 in an ATF3-dependent manner and increased the interaction between MZB cells and pre-TFH cells, leading to PDL1-mediated suppression of TFH cell motility, alteration of TFH cell differentiation, reduced TFH abundance and suppression of the proatherogenic TFH response. Our findings reveal a previously unsuspected role for MZB cells in controlling the TFH-germinal center response to a cholesterol-rich diet and uncover a PDL1-dependent mechanism through which MZB cells use their innate immune properties to limit an exaggerated adaptive immune response."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.4315"xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Marcus D."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Weller S."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Yeo G.S.H."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Masters L."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "de la Pompa J.L."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Binder C.J."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Figg N."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Finigan A."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Kitt L."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Mallat Z."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Lam B.Y.H."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Schirmbeck R."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Kneilling M."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Sage A.P."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Nus M."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Newland S."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Tsiantoulas D."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/author | "Raffort J."xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/28414328 | http://purl.uniprot.org/core/pages | "601-610"xsd:string |