| http://purl.uniprot.org/citations/28414795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28414795 | http://www.w3.org/2000/01/rdf-schema#comment | "Trimethylation of histone H3 lysine 4 and lysine 27 (H3K4me3 and H3K27me3) at gene promoter regions critically regulates gene expression. Key developmental genes tend to exhibit changes in histone modification patterns from the H3K4me3/H3K27me3 bivalent pattern to the H3K4me3 monovalent pattern. Using comprehensive chromatin immunoprecipitation followed by sequencing in bone marrow-derived macrophages (BMMs) and mature osteoclasts, we found that cell surface adhesion molecule 1 (Cadm1) is a direct target of nuclear factor of activated T cells 1 (NFATc1) and exhibits a bivalent histone pattern in BMMs and a monovalent pattern in osteoclasts. Cadm1 expression was upregulated in BMMs by receptor activator of nuclear factor kappa B ligand (RANKL), and blocked by a calcineurin/NFATc1 inhibitor, FK506. Cadm1-deficient mice exhibited significantly reduced bone mass compared with wild-type mice, which was due to the increased osteoclast differentiation, survival and bone-resorbing activity in Cadm1-deficient osteoclasts. These results suggest that Cadm1 is a direct target of NFATc1, which is induced by RANKL through epigenetic modification, and regulates osteoclastic bone resorption in a negative feedback manner."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0175632"xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Miyamoto T."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Nakamura S."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Nakamura M."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Nomura S."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Tanaka S."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Koyama T."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Aburatani H."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Minami T."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Momoi T."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Izawa N."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Omata Y."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/author | "Fujita-Jimbo E."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/pages | "e0175632"xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/title | "Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1."xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/28414795 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28414795 |
| http://purl.uniprot.org/citations/28414795 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28414795 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SS08-mappedCitation-28414795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28414795 |