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| http://purl.uniprot.org/citations/28416593 | http://www.w3.org/2000/01/rdf-schema#comment | "Multiple components have been identified that exhibit different stabilities for aversive olfactory memory in Drosophila These components have been defined by behavioral and genetic studies and genes specifically required for a specific component have also been identified. Intermediate-term memory generated after single cycle conditioning is divided into anesthesia-sensitive memory (ASM) and anesthesia-resistant memory (ARM), with the latter being more stable. We determined that the ASM and ARM pathways converged on the Rgk1 small GTPase and that the N-terminal domain-deleted Rgk1 was sufficient for ASM formation, whereas the full-length form was required for ARM formation. Rgk1 is specifically accumulated at the synaptic site of the Kenyon cells (KCs), the intrinsic neurons of the mushroom bodies, which play a pivotal role in olfactory memory formation. A higher than normal Rgk1 level enhanced memory retention, which is consistent with the result that Rgk1 suppressed Rac-dependent memory decay; these findings suggest that rgk1 bolsters ASM via the suppression of forgetting. We propose that Rgk1 plays a pivotal role in the regulation of memory stabilization by serving as a molecular node that resides at KC synapses, where the ASM and ARM pathway may interact.SIGNIFICANCE STATEMENT Memory consists of multiple components. Drosophila olfactory memory serves as a fundamental model with which to investigate the mechanisms that underlie memory formation and has provided genetic and molecular means to identify the components of memory, namely short-term, intermediate-term, and long-term memory, depending on how long the memory lasts. Intermediate memory is further divided into anesthesia-sensitive memory (ASM) and anesthesia-resistant memory (ARM), with the latter being more stable. We have identified a small GTPase in Drosophila, Rgk1, which plays a pivotal role in the regulation of olfactory memory stability. Rgk1 is required for both ASM and ARM. Moreover, N-terminal domain-deleted Rgk1 was sufficient for ASM formation, whereas the full-length form was required for ARM formation."xsd:string |
| http://purl.uniprot.org/citations/28416593 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3648-16.2017"xsd:string |
| http://purl.uniprot.org/citations/28416593 | http://purl.uniprot.org/core/author | "Shirahige K."xsd:string |
| http://purl.uniprot.org/citations/28416593 | http://purl.uniprot.org/core/author | "Murakami S."xsd:string |
| http://purl.uniprot.org/citations/28416593 | http://purl.uniprot.org/core/author | "Nakato R."xsd:string |
| http://purl.uniprot.org/citations/28416593 | http://purl.uniprot.org/core/author | "Tabata T."xsd:string |
| http://purl.uniprot.org/citations/28416593 | http://purl.uniprot.org/core/author | "Minami-Ohtsubo M."xsd:string |
| http://purl.uniprot.org/citations/28416593 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28416593 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/28416593 | http://purl.uniprot.org/core/pages | "5496-5510"xsd:string |
| http://purl.uniprot.org/citations/28416593 | http://purl.uniprot.org/core/title | "Two Components of Aversive Memory in Drosophila, Anesthesia-Sensitive and Anesthesia-Resistant Memory, Require Distinct Domains Within the Rgk1 Small GTPase."xsd:string |
| http://purl.uniprot.org/citations/28416593 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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