| http://purl.uniprot.org/citations/28416686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28416686 | http://www.w3.org/2000/01/rdf-schema#comment | "Sensory nerves emanating from the dorsal root extensively innervate the surfaces of mammalian bone, a privileged location for the regulation of biomechanical signaling. Here, we show that NGF-TrkA signaling in skeletal sensory nerves is an early response to mechanical loading of bone and is required to achieve maximal load-induced bone formation. First, the elimination of TrkA signaling in mice harboring mutant TrkAF592A alleles was found to greatly attenuate load-induced bone formation induced by axial forelimb compression. Next, both in vivo mechanical loading and in vitro mechanical stretch were shown to induce the profound up-regulation of NGF in osteoblasts within 1 h of loading. Furthermore, inhibition of TrkA signaling following axial forelimb compression was observed to reduce measures of Wnt/β-catenin activity in osteocytes in the loaded bone. Finally, the administration of exogenous NGF to wild-type mice was found to significantly increase load-induced bone formation and Wnt/β-catenin activity in osteocytes. In summary, these findings demonstrate that communication between osteoblasts and sensory nerves through NGF-TrkA signaling is essential for load-induced bone formation in mice."xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1701054114"xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://purl.uniprot.org/core/author | "Venkatesan A."xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://purl.uniprot.org/core/author | "Tomlinson R.E."xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://purl.uniprot.org/core/author | "Li Z.'"xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://purl.uniprot.org/core/author | "Minichiello L."xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://purl.uniprot.org/core/author | "Clemens T.L."xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://purl.uniprot.org/core/author | "Riddle R.C."xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28416686 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://purl.uniprot.org/core/pages | "E3632-E3641"xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://purl.uniprot.org/core/title | "NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice."xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/28416686 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28416686 |
| http://purl.uniprot.org/citations/28416686 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28416686 |
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