| http://purl.uniprot.org/citations/28421673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28421673 | http://www.w3.org/2000/01/rdf-schema#comment | "AimsThe receptor tyrosine kinase ErbB4 is present throughout the primate brain and has a distinct functional profile. In this study, we investigate the potential role of endothelial ErbB4 receptor signaling in the brain.ResultsHere, we show that the endothelial cell-specific deletion of ErbB4 induces decreased exploratory behavior in adult mice. However, the water maze task for spatial memory and the memory reconsolidation test reveal no changes; additionally, we observe no impairment in CaMKII phosphorylation in Cdh5Cre;ErbB4f/f mice, which indicates that the endothelial ErbB4 deficit leads to decreased exploratory activity rather than direct memory deficits. Furthermore, decreased brain metabolism, which was measured using micro-positron emission tomography, is observed in the Cdh5Cre;ErbB4f/f mice. Consistently, the immunoblot data demonstrate the downregulation of brain Glut1, phospho-ULK1 (Ser555), and TIGAR in the endothelial ErbB4 conditional knockout mice. Collectively, our findings suggest that endothelial ErbB4 plays a critical role in regulating brain function, at least in part, through maintaining normal brain energy homeostasis.ConclusionsTargeting ErbB4 or the modulation of endothelial ErbB4 signaling may represent a rational pharmacological approach to treat neurological disorders."xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.org/dc/terms/identifier | "doi:10.1111/cns.12695"xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/author | "Han F."xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/author | "Liu X.X."xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/author | "Wu G."xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/author | "Jiang G.J."xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/author | "Lu Y.M."xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/author | "Liu Q.B."xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/author | "Lu N.N."xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/author | "Tao R.R."xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/author | "Ye W.F."xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/name | "CNS Neurosci Ther"xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/pages | "510-517"xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/title | "Endothelial ErbB4 deficit induces alterations in exploratory behavior and brain energy metabolism in mice."xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/28421673 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28421673 |
| http://purl.uniprot.org/citations/28421673 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28421673 |
| http://purl.uniprot.org/uniprot/#_B2KGF7-mappedCitation-28421673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28421673 |
| http://purl.uniprot.org/uniprot/#_O88459-mappedCitation-28421673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28421673 |
| http://purl.uniprot.org/uniprot/#_Q61527-mappedCitation-28421673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28421673 |
| http://purl.uniprot.org/uniprot/Q61527 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28421673 |
| http://purl.uniprot.org/uniprot/O88459 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28421673 |