| http://purl.uniprot.org/citations/28422240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28422240 | http://www.w3.org/2000/01/rdf-schema#comment | "We synthesized and evaluated new zwitterionic inhibitors against glycoside hydrolase-like phosphorylase Streptomyces coelicolor (Sco) GlgEI-V279S which plays a role in α-glucan biosynthesis. Sco GlgEI-V279S serves as a model enzyme for validated anti-tuberculosis (TB) target Mycobacterium tuberculosis (Mtb) GlgE. Pyrrolidine inhibitors 5 and 6 were designed based on transition state considerations and incorporate a phosphonate on the pyrrolidine moiety to expand the interaction network between the inhibitor and the enzyme active site. Compounds 5 and 6 inhibited Sco GlgEI-V279S with Ki = 45 ± 4 μM and 95 ± 16 μM, respectively, and crystal structures of Sco GlgE-V279S-5 and Sco GlgE-V279S-6 were obtained at a 3.2 Å and 2.5 Å resolution, respectively."xsd:string |
| http://purl.uniprot.org/citations/28422240 | http://purl.org/dc/terms/identifier | "doi:10.1039/c7ob00388a"xsd:string |
| http://purl.uniprot.org/citations/28422240 | http://purl.uniprot.org/core/author | "Petit C."xsd:string |
| http://purl.uniprot.org/citations/28422240 | http://purl.uniprot.org/core/author | "Ronning D.R."xsd:string |
| http://purl.uniprot.org/citations/28422240 | http://purl.uniprot.org/core/author | "Sucheck S.J."xsd:string |
| http://purl.uniprot.org/citations/28422240 | http://purl.uniprot.org/core/author | "Veleti S.K."xsd:string |
| http://purl.uniprot.org/citations/28422240 | http://purl.uniprot.org/core/author | "Lindenberger"xsd:string |
| http://purl.uniprot.org/citations/28422240 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28422240 | http://purl.uniprot.org/core/name | "Org Biomol Chem"xsd:string |
| http://purl.uniprot.org/citations/28422240 | http://purl.uniprot.org/core/pages | "3884-3891"xsd:string |
| http://purl.uniprot.org/citations/28422240 | http://purl.uniprot.org/core/title | "Zwitterionic pyrrolidene-phosphonates: inhibitors of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S."xsd:string |
| http://purl.uniprot.org/citations/28422240 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/28422240 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28422240 |
| http://purl.uniprot.org/citations/28422240 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28422240 |
| http://purl.uniprot.org/uniprot/#_Q9L1K2-mappedCitation-28422240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28422240 |
| http://purl.uniprot.org/uniprot/Q9L1K2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28422240 |