| http://purl.uniprot.org/citations/28428082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28428082 | http://www.w3.org/2000/01/rdf-schema#comment | "Almost all primary prostate cancers (PCs) and PC cell lines express calcitonin (CT) and/or its receptor (CTR), and their co-expression positively correlates with their invasiveness. Activation of the CT-CTR axis in non-invasive LNCaP cells induces an invasive phenotype. In contrast, silencing of CT/CTR expression in highly metastatic PC-3M cells markedly reduces their tumorigenicity and abolishes their ability to form distant metastases in nude mice. Our recent studies suggest that CTR interacts with zonula occludens 1 (ZO-1) through PDZ interaction to destabilize tight junctions and increase invasion of PC cells. Our results show that CTR activates AKAP2-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 and claudin 3. Moreover, PKA-mediated phosphorylation of tight unction proteins required CTR-ZO-1 interaction, suggesting that the interaction may bring CTR-activated PKA in close proximity of tight junction proteins. Furthermore, inhibition of PKA activity attenuated CT-induced loss of TJ functionality and invasion, suggesting that the phosphorylation of TJ proteins is responsible for TJ disassembly. Finally, we show that the prevention of CTR-ZO-1 interaction abolishes CT-induced invasion, and can serve as a novel therapeutic tool to treat aggressive prostate cancers. In brief, the present study identifies the significance of CTR-ZO-1 interaction in progression of prostate cancer to its metastatic form."xsd:string |
| http://purl.uniprot.org/citations/28428082 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2017.04.008"xsd:string |
| http://purl.uniprot.org/citations/28428082 | http://purl.uniprot.org/core/author | "Shah G."xsd:string |
| http://purl.uniprot.org/citations/28428082 | http://purl.uniprot.org/core/author | "Thakkar A."xsd:string |
| http://purl.uniprot.org/citations/28428082 | http://purl.uniprot.org/core/author | "Aljameeli A."xsd:string |
| http://purl.uniprot.org/citations/28428082 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28428082 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/28428082 | http://purl.uniprot.org/core/pages | "1-13"xsd:string |
| http://purl.uniprot.org/citations/28428082 | http://purl.uniprot.org/core/title | "Calcitonin receptor increases invasion of prostate cancer cells by recruiting zonula occludens-1 and promoting PKA-mediated TJ disassembly."xsd:string |
| http://purl.uniprot.org/citations/28428082 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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