| http://purl.uniprot.org/citations/28438789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28438789 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular vesicles (EVs) are nanoscale membrane-derived vesicles that serve as intercellular messengers carrying lipids, proteins, and genetic material. Substantial evidence has shown that cancer-derived EVs, secreted by tumor cells into the blood and other bodily fluids, play a critical role in modulating the tumor microenvironment and affecting the pathogenesis of cancer. Here we demonstrate for the first time that squamous cell carcinoma (SCC) EVs were enriched with the C-terminal fragment of desmoglein 2 (Dsg2), a desmosomal cadherin often overexpressed in malignancies. Overexpression of Dsg2 increased EV release and mitogenic content including epidermal growth factor receptor and c-Src. Inhibiting ectodomain shedding of Dsg2 with the matrix metalloproteinase inhibitor GM6001 resulted in accumulation of full-length Dsg2 in EVs and reduced EV release. When cocultured with Dsg2/green fluorescence protein-expressing SCC cells, green fluorescence protein signal was detected by fluorescence-activated cell sorting analysis in the CD90+ fibroblasts. Furthermore, SCC EVs activated Erk1/2 and Akt signaling and enhanced fibroblast cell proliferation. In vivo, Dsg2 was highly up-regulated in the head and neck SCCs, and EVs isolated from sera of patients with SCC were enriched in Dsg2 C-terminal fragment and epidermal growth factor receptor. This study defines a mechanism by which Dsg2 expression in cancer cells can modulate the tumor microenvironment, a step critical for tumor progression.-Overmiller, A. M., Pierluissi, J. A., Wermuth, P. J., Sauma, S., Martinez-Outschoorn, U., Tuluc, M., Luginbuhl, A., Curry, J., Harshyne, L. A., Wahl, J. K. III, South, A. P., Mahoney, M. G. Desmoglein 2 modulates extracellular vesicle release from squamous cell carcinoma keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.201601138rr"xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/author | "South A.P."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/author | "Curry J."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/author | "Mahoney M.G."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/author | "Wahl J.K."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/author | "Tuluc M."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/author | "Wermuth P.J."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/author | "Martinez-Outschoorn U."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/author | "Luginbuhl A."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/author | "Overmiller A.M."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/author | "Harshyne L.A."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/author | "Pierluissi J.A."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/author | "Sauma S."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/pages | "3412-3424"xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/title | "Desmoglein 2 modulates extracellular vesicle release from squamous cell carcinoma keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/28438789 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28438789 |
| http://purl.uniprot.org/citations/28438789 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28438789 |
| http://purl.uniprot.org/uniprot/#_Q14126-mappedCitation-28438789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28438789 |
| http://purl.uniprot.org/uniprot/#_Q8WWR7-mappedCitation-28438789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28438789 |
| http://purl.uniprot.org/uniprot/Q8WWR7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28438789 |