| http://purl.uniprot.org/citations/28441586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28441586 | http://www.w3.org/2000/01/rdf-schema#comment | "Emerged porcine kobuvirus (PKV) has adversely affected the global swine industry since 2008, but the etiological biology of PKV is unclear. Screening PKV-encoded structural and non-structural proteins with a type I IFN-responsive luciferase reporter showed that PKV VP3 protein inhibited the IFN-β-triggered signaling pathway, resulting in the decrease of VSV-GFP replication. QPCR data showed that IFN-β downstream cytokine genes were suppressed without cell-type specificity as well. The results from biochemical experiments indicated that PKV VP3 associated with STAT2 and IRF9, and interfered with the formation of the STAT2-IRF9 and STAT2-STAT2 complex, impairing nuclear translocation of STAT2 and IRF9. Taken together, these data reveal a new mechanism for immune evasion of PKV."xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2017.04.023"xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/author | "Ren Y."xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/author | "Zhu Q."xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/author | "Zhong B."xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/author | "Lan X."xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/author | "Peng Q."xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/author | "Yue N."xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/pages | "161-169"xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/title | "Kobuvirus VP3 protein restricts the IFN-beta-triggered signaling pathway by inhibiting STAT2-IRF9 and STAT2-STAT2 complex formation."xsd:string |
| http://purl.uniprot.org/citations/28441586 | http://purl.uniprot.org/core/volume | "507"xsd:string |
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