Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/28454690http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28454690http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

Soluble fms-like tyrosine kinase 1 (sFLT-1) is an anti-angiogenic factor implicated in the pathogenesis of preterm preeclampsia. We evaluated sFLT-1 expression and placental pathology in pregnancies complicated by small for gestational age (SGA) infants (<10th percentile), without evidence of preeclampsia.

Methods

Clinical and histologic data were compared between groups with high or low sFLT-1 expression determined by immunohistochemistry on archived placentas.

Results

Nineteen of 69 placentas showed high sFLT-1 expression. The high sFLT-1 group had higher predelivery median systolic blood pressure (BP); 140 (interquartile range (IQR) 133-152) vs. 126 (118-139) mm Hg (p = 0.003), and median diastolic BP; 87 (78-94) vs. 77.5 (71-86) mm Hg (p = 0.02). Abnormal umbilical Doppler abnormalities were more prevalent; 89.5% vs. 46% (p = 0.001). These pregnancies delivered earlier; 31.9 weeks (28.3-34.7 weeks) vs. 37.1 weeks (33.7-38.7 weeks) (p < 0.001), and infants had lower birthweight; 980 grams (520-1545 grams) vs. 2087.5 grams (1455-2340 grams) (p < 0.001). Placental-weight to fetal-weight ratios, a marker of vascular insufficiency, was increased in the high sFlt-1 group: 0.18 (0.14-0.28) vs 0.15 (0.13-0.18), p = 0.03. Placentas with high sFLT-1 showed more decidual vasculopathy; 42.1% vs. 10.0% (p = 0.005), infarction; 36.8% vs. 14.0% (p = 0.048), distal villous hypoplasia; 78.9% vs. 36.0% (p = 0.001), and fetal thrombotic vasculopathy; 47.4% vs. 16.0% (p = 0.01).

Discussion

Placental sFLT-1 expression is upregulated in approximately 28% of non-preeclamptic pregnancies complicated by SGA infants. These pregnancies showed increased placental vascular pathology, more umbilical Doppler abnormalities, and earlier delivery with lower birthweight. A subgroup of non-preeclamptic fetal growth restriction with upregulated sFlt-1 expression may share a common pathogenic pathway with preterm preeclampsia. This subgroup is worthy of additional study."xsd:string
http://purl.uniprot.org/citations/28454690http://purl.org/dc/terms/identifier"doi:10.1016/j.placenta.2017.02.011"xsd:string
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/author"Wang A."xsd:string
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/author"Salahuddin S."xsd:string
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/author"Karumanchi S.A."xsd:string
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/author"Hecht J.L."xsd:string
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/author"Zsengeller Z."xsd:string
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/author"Modest A.M."xsd:string
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/author"Pernicone E."xsd:string
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/author"Spiel M."xsd:string
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/name"Placenta"xsd:string
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/pages"10-16"xsd:string
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/title"Placental soluble fms-like tyrosine kinase expression in small for gestational age infants and risk for adverse outcomes."xsd:string
http://purl.uniprot.org/citations/28454690http://purl.uniprot.org/core/volume"52"xsd:string
http://purl.uniprot.org/citations/28454690http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28454690
http://purl.uniprot.org/citations/28454690http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/28454690
http://purl.uniprot.org/uniprot/#_H9N1E7-mappedCitation-28454690http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28454690
http://purl.uniprot.org/uniprot/#_H9N1E8-mappedCitation-28454690http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28454690
http://purl.uniprot.org/uniprot/#_B5A924-mappedCitation-28454690http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28454690
http://purl.uniprot.org/uniprot/#_B1AC84-mappedCitation-28454690http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28454690
http://purl.uniprot.org/uniprot/#_P17948-mappedCitation-28454690http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28454690
http://purl.uniprot.org/uniprot/#_L7RSL3-mappedCitation-28454690http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28454690
http://purl.uniprot.org/uniprot/#_Q16332-mappedCitation-28454690http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28454690
▶