| http://purl.uniprot.org/citations/28455267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28455267 | http://www.w3.org/2000/01/rdf-schema#comment | "Numerous epidemiological studies suggested that there is a variable cancer risk in patients with Parkinson's disease (PD). However, the underlying mechanisms remain unclear. In the present study, the role of metabotropic glutamate receptor 5 (mGluR5) has been investigated in 6-hydroxydopamine (6-OHDA)-induced PD combined with liver cancer both in vitro and in vivo. We found that PD cellular model from 6-OHDA-lesioned MN9D cells suppressed the growth, migration, and invasion of Hepa1-6 cells via down-regulation of mGluR5-mediated ERK and Akt pathway. The application of 2-methyl-6-(phenylethyl)-pyridine and knockdown of mGluR5 further decreased the effect on Hepa-1-6 cells when co-cultured with conditioned media. The effect was increased by (S)-3,5-dihydroxyphenylglycine and overexpression of mGluR5. Moreover, more release of glutamate from 6-OHDA-lesioned MN9D cells suppressed mGluR5-mediated effect of Hepa1-6 cells. Application of riluzole eliminated the increased glutamate release induced by 6-OHDA in MN9D cells and aggravated the suppressive effect on Hepa-1-6 cells. In addition, the growth of implanted liver cancer was inhibited in 6-OHDA induced PD-like rats, and was associated with increased glutamate release in the serum and down-regulation of mGluR5 in tumor tissue. Collectively, these results indicate that selective antagonism of glutamate and mGluR5 has a potentially beneficial effect in both liver cancer and PD, and thus may provide more understanding for the clinical investigation and further an additional therapeutic target for these two diseases."xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.phrs.2017.04.026"xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/author | "Gu L."xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/author | "Yang H.M."xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/author | "Wang X.M."xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/author | "An W."xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/author | "Bai X.X."xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/author | "Bao L.H."xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/author | "Xi S.S."xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/name | "Pharmacol Res"xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/pages | "145-157"xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/title | "Metabotropic glutamate receptor 5 mediates the suppressive effect of 6-OHDA-induced model of Parkinson's disease on liver cancer."xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://purl.uniprot.org/core/volume | "121"xsd:string |
| http://purl.uniprot.org/citations/28455267 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28455267 |
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