| http://purl.uniprot.org/citations/28456658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28456658 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute myelogenous leukemia (AML) is a clinically heterogeneous disease that is frequently associated with relapse and a poor prognosis. Among the various subtypes, AML with the monosomal karyotype (AML-MK) has an extremely unfavorable prognosis. We performed screening to identify antitumor compounds that are capable of inducing apoptosis in primary leukemia cells harboring the AML-MK karyotype and identified a naturally occurring stilbene, Gnetin-C, with potent anti-tumor activities against AML cells from patients with various cytogenetic abnormalities, including patients with the AML-MK karyotype. Gnetin-C simultaneously inhibits the ERK1/2 and the AKT/mTOR pathways, two signals that are essential for the survival of leukemia cells. A combination of Gnetin-C with low doses of chemotherapeutic drugs led to synergistic anti-tumor effects against AML cells. In an immunodeficient mouse model of human leukemia, Gnetin-C attenuated the formation of leukemia, depleted leukemia cells and improved survival. These findings suggest that Gnetin-C has antitumor activities in AML and supports the therapeutic potential of blocking two different pathways in AML."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2017.04.027"xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/author | "Harada K."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/author | "Nakao S."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/author | "Nakagawa N."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/author | "Yamauchi T."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/author | "Taniwaki M."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/author | "Ishiyama K."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/author | "Takenaka K."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/author | "Espinoza J.L."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/author | "Takami A."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/author | "Trung L.Q."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/author | "Elbadry M.I."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/pages | "127-136"xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/title | "The simultaneous inhibition of the mTOR and MAPK pathways with Gnetin-C induces apoptosis in acute myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://purl.uniprot.org/core/volume | "400"xsd:string |
| http://purl.uniprot.org/citations/28456658 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28456658 |
| http://purl.uniprot.org/citations/28456658 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28456658 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TQ52-mappedCitation-28456658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28456658 |
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| http://purl.uniprot.org/uniprot/#_B3KX59-mappedCitation-28456658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28456658 |
| http://purl.uniprot.org/uniprot/#_B4E2H2-mappedCitation-28456658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28456658 |