| http://purl.uniprot.org/citations/28459371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28459371 | http://www.w3.org/2000/01/rdf-schema#comment | "There is an obvious need to diagnose hepatocellular carcinoma using novel non-invasive and sensitive biomarkers. In this regard, the aim of this study was to evaluate and correlate both relative quantification of microRNA-7 using quantitative real time polymerase chain reaction and quantitative analysis of selenoprotein P using enzyme-linked immunosorbent assay in sera of hepatocellular carcinoma patients, chronic liver disease patients, as well as normal healthy subjects in order to establish a new diagnostic biomarker with a valid non-invasive technique. In addition, this study aimed to investigate whether changes in selenium supply affect microRNA-7 expression and selenoprotein P levels in human hepatocarcinoma cell line (HepG2). The results showed a highly significant decrease in serum microRNA-7 relative quantification values and selenoprotein P levels in malignant group in comparison with benign and control groups. The best cutoff for serum microRNA-7 and selenoprotein P to discriminate hepatocellular carcinoma group from benign and control groups was 0.06 and 4.30 mg/L, respectively. Furthermore, this study showed that changes in selenium supply to HepG2 cell line can alter the microRNA-7 profile and are paralleled by changes in the concentration of its target protein (selenoprotein P). Hence, serum microRNA-7 and selenoprotein P appear to be potential non-invasive diagnostic markers for hepatocellular carcinoma. Moreover, the results suggest that selenium could be used as an anticancer therapy for hepatocellular carcinoma by affecting both microRNA-7 and selenoprotein P."xsd:string |
| http://purl.uniprot.org/citations/28459371 | http://purl.org/dc/terms/identifier | "doi:10.1177/1010428317698372"xsd:string |
| http://purl.uniprot.org/citations/28459371 | http://purl.uniprot.org/core/author | "Ali-Labib R."xsd:string |
| http://purl.uniprot.org/citations/28459371 | http://purl.uniprot.org/core/author | "Montasser I.F."xsd:string |
| http://purl.uniprot.org/citations/28459371 | http://purl.uniprot.org/core/author | "Tarek M."xsd:string |
| http://purl.uniprot.org/citations/28459371 | http://purl.uniprot.org/core/author | "Louka M.L."xsd:string |
| http://purl.uniprot.org/citations/28459371 | http://purl.uniprot.org/core/author | "Khairy E."xsd:string |
| http://purl.uniprot.org/citations/28459371 | http://purl.uniprot.org/core/author | "Zakaria Zaky D."xsd:string |
| http://purl.uniprot.org/citations/28459371 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28459371 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/28459371 | http://purl.uniprot.org/core/pages | "1010428317698372"xsd:string |
| http://purl.uniprot.org/citations/28459371 | http://purl.uniprot.org/core/title | "Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/28459371 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/28459371 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28459371 |
| http://purl.uniprot.org/citations/28459371 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28459371 |
| http://purl.uniprot.org/uniprot/#_P49908-mappedCitation-28459371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28459371 |
| http://purl.uniprot.org/uniprot/P49908 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28459371 |