| http://purl.uniprot.org/citations/28460433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28460433 | http://www.w3.org/2000/01/rdf-schema#comment | "A label free quantitative proteomic approach (SWATH™ experiment) was performed to identify tumor-associated nuclear proteins that are differentially expressed between osteosarcoma cells and osteoblast cells. By functional screening, minichromosome maintenance protein 2 (MCM2) and minichromosome maintenance protein 3 (MCM3) were found to be related to osteosarcoma cell growth. Here, we show that knockdown of MCM2 or MCM3 inhibits osteosarcoma growth in vitro and in vivo. In co-immunoprecipitation and co-localization experiments, MCM2 and MCM3 were found to interact with DExH-box helicase 9 (DHX9) in osteosarcoma cells. A rescue study showed that the decreased growth of osteosarcoma cells by MCM2 or MCM3 knockdown was reversed by DHX9 overexpression, indicating that MCM2 and MCM3 activity was DHX9-dependent. In addition, the depletion of DHX9 hindered osteosarcoma cell proliferation. Notably, MCM2 and MCM3 expression levels were positively correlated with the DHX9 expression level in tumor samples and were associated with a poor prognosis in patients with osteosarcoma. Taken together, these results suggest that the MCM2/MCM3-DHX9 axis has an important role in osteosarcoma progression."xsd:string |
| http://purl.uniprot.org/citations/28460433 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.15474"xsd:string |
| http://purl.uniprot.org/citations/28460433 | http://purl.uniprot.org/core/author | "Fan C.Y."xsd:string |
| http://purl.uniprot.org/citations/28460433 | http://purl.uniprot.org/core/author | "Li S.J."xsd:string |
| http://purl.uniprot.org/citations/28460433 | http://purl.uniprot.org/core/author | "Zhang H.Z."xsd:string |
| http://purl.uniprot.org/citations/28460433 | http://purl.uniprot.org/core/author | "Yuan J.Q."xsd:string |
| http://purl.uniprot.org/citations/28460433 | http://purl.uniprot.org/core/author | "Yang Q.C."xsd:string |
| http://purl.uniprot.org/citations/28460433 | http://purl.uniprot.org/core/author | "Cheng D.D."xsd:string |
| http://purl.uniprot.org/citations/28460433 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28460433 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/28460433 | http://purl.uniprot.org/core/pages | "26380-26393"xsd:string |
| http://purl.uniprot.org/citations/28460433 | http://purl.uniprot.org/core/title | "Minichromosome maintenance protein 2 and 3 promote osteosarcoma progression via DHX9 and predict poor patient prognosis."xsd:string |
| http://purl.uniprot.org/citations/28460433 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/28460433 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28460433 |
| http://purl.uniprot.org/citations/28460433 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28460433 |
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| http://purl.uniprot.org/uniprot/#_A0A0S2Z492-mappedCitation-28460433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28460433 |
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| http://purl.uniprot.org/uniprot/#_B3KXZ4-mappedCitation-28460433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28460433 |
| http://purl.uniprot.org/uniprot/#_B4DUQ9-mappedCitation-28460433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28460433 |
| http://purl.uniprot.org/uniprot/#_B4DS46-mappedCitation-28460433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28460433 |
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