| http://purl.uniprot.org/citations/28466852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28466852 | http://www.w3.org/2000/01/rdf-schema#comment | "Low-grade inflammation links obesity to insulin resistance through the activation of tissue-infiltrating immune cells. Interleukin-6 (IL-6) is a crucial regulator of T cells and is increased in obesity. Here we report that classical IL-6 signalling in T cells promotes inflammation and insulin resistance during the first 8 weeks on a high-fat diet (HFD), but becomes dispensable at later stages (after 16 weeks). Mice with T cell-specific deficiency of IL-6 receptor-α (IL-6RαT-KO) exposed to a HFD display improved glucose tolerance, insulin sensitivity and inflammation in liver and EWAT after 8 weeks. However, after 16 weeks, insulin resistance in IL-6RαT-KO epididymal white adipose tissue (EWAT) is comparable to that of controls, whereas the inflammatory profile is significantly worse. This coincided with a shift from classical T cell IL-6 signalling at 8 weeks, to enhanced IL-6 trans-signalling at 16 weeks. Collectively, our studies reveal that IL-6 action in T cells through classical IL-6 signalling promotes inflammation and insulin resistance early during obesity development, which can be compensated for by enhanced IL-6 trans-signalling at later stages."xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms14803"xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/author | "Xu E."xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/author | "Waisman A."xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/author | "Rappl G."xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/author | "Bruning J.C."xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/author | "Wunderlich F.T."xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/author | "Theurich S."xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/author | "Pereira M.M.A."xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/author | "Karakasilioti I."xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/author | "Al-Maarri M."xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/pages | "14803"xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/title | "Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance."xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/28466852 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28466852 |
| http://purl.uniprot.org/citations/28466852 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28466852 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF1-mappedCitation-28466852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28466852 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-28466852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28466852 |
| http://purl.uniprot.org/uniprot/#_Q0PMN1-mappedCitation-28466852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28466852 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFG1-mappedCitation-28466852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28466852 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFT1-mappedCitation-28466852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28466852 |
| http://purl.uniprot.org/uniprot/#_A0A1C9J7U0-mappedCitation-28466852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28466852 |