| http://purl.uniprot.org/citations/28467410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28467410 | http://www.w3.org/2000/01/rdf-schema#comment | "The fate of neural progenitor cells (NPCs) during corticogenesis is determined by a complex interplay of genetic or epigenetic components, but the underlying mechanism is incompletely understood. Here, we demonstrate that Suppressor of Mek null (Smek) interact with methyl-CpG-binding domain 3 (Mbd3) and the complex plays a critical role in self-renewal and neuronal differentiation of NPCs. We found that Smek promotes Mbd3 polyubiquitylation and degradation, blocking recruitment of the repressive Mbd3/nucleosome remodeling and deacetylase (NuRD) complex at the neurogenesis-associated gene loci, and, as a consequence, increasing acetyl histone H3 activity and cortical neurogenesis. Furthermore, overexpression of Mbd3 significantly blocked neuronal differentiation of NPCs, and Mbd3 depletion rescued neurogenesis defects seen in Smek1/2 knockout mice. These results reveal a novel molecular mechanism underlying Smek/Mbd3/NuRD axis-mediated control of NPCs' self-renewal and neuronal differentiation during mammalian corticogenesis."xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.2001220"xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://purl.uniprot.org/core/author | "Choi S.H."xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://purl.uniprot.org/core/author | "Cai M."xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://purl.uniprot.org/core/author | "Chang W.H."xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://purl.uniprot.org/core/author | "Moon B.S."xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://purl.uniprot.org/core/author | "Yun H.M."xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://purl.uniprot.org/core/author | "Steele B.H."xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28467410 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://purl.uniprot.org/core/pages | "e2001220"xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://purl.uniprot.org/core/title | "Smek promotes corticogenesis through regulating Mbd3's stability and Mbd3/NuRD complex recruitment to genes associated with neurogenesis."xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/28467410 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28467410 |
| http://purl.uniprot.org/citations/28467410 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28467410 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-28467410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28467410 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-28467410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28467410 |
| http://purl.uniprot.org/uniprot/#_P63015-mappedCitation-28467410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28467410 |
| http://purl.uniprot.org/uniprot/#_A2AR81-mappedCitation-28467410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28467410 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VJG9-mappedCitation-28467410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28467410 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VMI3-mappedCitation-28467410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28467410 |
| http://purl.uniprot.org/uniprot/#_A2A409-mappedCitation-28467410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28467410 |
| http://purl.uniprot.org/uniprot/#_A2A412-mappedCitation-28467410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28467410 |