| http://purl.uniprot.org/citations/28469175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28469175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28469175 | http://www.w3.org/2000/01/rdf-schema#comment | "Innate immunity plays a pivotal role in virus infection. RIG-I senses viral RNA and initiates an effective innate immune response for type I interferon production. To transduce RIG-I-mediated antiviral signalling, a mitochondrial protein MAVS forms prion-like aggregates to activate downstream kinases and transcription factors. However, the activation mechanism of RIG-I is incompletely understood. Here we identify two ubiquitin enzymes Ube2D3 and Ube2N through chromatographic purification as activators for RIG-I on virus infection. We show that together with ubiquitin ligase Riplet, Ube2D3 promotes covalent conjugation of polyubiquitin chains to RIG-I, while Ube2N preferentially facilitates production of unanchored polyubiquitin chains. In the presence of these polyubiquitin chains, RIG-I induces MAVS aggregation directly on the mitochondria. Our data thus reveal two essential polyubiquitin-mediated mechanisms underlying the activation of RIG-I and MAVS for triggering innate immune signalling in response to viral infection in cells."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms15138"xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms15138"xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Yuan B."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Yuan B."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Hao X."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Hao X."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Hou F."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/author | "Hou F."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/28469175 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |