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http://purl.uniprot.org/citations/28471517http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28471517http://www.w3.org/2000/01/rdf-schema#comment"

Background

The Duffy antigen receptor for chemokines (DARC) is an atypical receptor that regulates pro-inflammatory cytokines. However, the role of DARC in asthma pathophysiology is unknown.

Objective

To determine the role of DARC in allergic airways disease in mice, and the association between DARC single nucleotide polymorphisms (SNPs) and clinical outcomes in patients with asthma.

Methods

Mice with targeted disruption of the Darc gene (Darc∆E2 ) or WT mice were challenged over 3 weeks with house dust mite (HDM) antigen. Allergic airways disease was assessed 24 hours and 7 days following the final challenge. Additionally, associations between DARC SNPs and clinical outcomes were analysed in a cohort of poorly controlled asthmatics.

Results

Total airway inflammation following HDM did not differ between Darc∆E2 and WT mice. At 24 hours, Darc∆E2 mice had increased airway hyperresponsiveness; however, at 7 days airway hyperresponsiveness had completely resolved in Darc∆E2 but persisted in WT mice. In poorly controlled asthmatics, DARC SNPs were associated with worse asthma control at randomization and subsequent increased risk of healthcare utilization (odds ratio 3.13(1.37-7.27), P=.0062).

Conclusions and clinical relevance

Our animal model and human patient data suggest a novel role for DARC in the temporal regulation in asthma pathophysiology and symptoms."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.org/dc/terms/identifier"doi:10.1111/cea.12949"xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Worthen G.S."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Hoffman S.M."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Schneider R.W."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Lima J.J."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Peters S.P."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Mougey E.B."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Poynter M.E."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Lahue K.G."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Irvin C.G."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Tracy R.P."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Aliyeva M."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Daphtary N."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Chapman D.G."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"George K.L."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Janssen-Heininger Y.M.W."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/author"Van der Velden J.L."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/name"Clin Exp Allergy"xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/pages"1214-1222"xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/title"The Duffy antigen receptor for chemokines regulates asthma pathophysiology."xsd:string
http://purl.uniprot.org/citations/28471517http://purl.uniprot.org/core/volume"47"xsd:string
http://purl.uniprot.org/citations/28471517http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28471517
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