| http://purl.uniprot.org/citations/28475838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28475838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28475838 | http://www.w3.org/2000/01/rdf-schema#comment | "Types of polyketide synthase-terpenoid synthase (PKS-TPS) hybrid metabolites, including arthrosporols with significant morphological regulatory activity, have been elucidated from nematode-trapping fungus Arthrobotrys oligospora. A previous study suggested that the gene cluster AOL_s00215 in A. oligospora was involved in the production of arthrosporols. Here, we report that disruption of one cytochrome P450 monooxygenase gene AOL_s00215g280 in the cluster resulted in significant phenotypic difference and much aerial hyphae. A further bioassay indicated that the mutant showed a dramatic decrease in the conidial formation but developed numerous traps and killed 85% nematodes within 6 h in contact with prey, in sharp contrast to the wild-type strain with no obvious response. Chemical investigation revealed huge accumulation of three new PKS-TPS epoxycyclohexone derivatives with different oxygenated patterns around the epoxycyclohexone moiety and the absence of arthrosporols in the cultural broth of the mutant ΔAOL_s00215g280. These findings suggested that a study on the biosynthetic pathway for morphological regulatory metabolites in nematode-trapping fungus would provide an efficient way to develop new fungal biocontrol agents."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.org/dc/terms/identifier | "doi:10.1021/acs.jafc.7b01290"xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.org/dc/terms/identifier | "doi:10.1021/acs.jafc.7b01290"xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Chen Y.H."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Chen Y.H."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Miao Y."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Miao Y."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Ding Q.Y."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Ding Q.Y."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Niu X.M."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Niu X.M."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Song T.Y."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Song T.Y."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Sun Y.R."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Sun Y.R."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Xu Z.F."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Xu Z.F."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Zhang K.Q."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/author | "Zhang K.Q."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/name | "J. Agric. Food Chem."xsd:string |
| http://purl.uniprot.org/citations/28475838 | http://purl.uniprot.org/core/name | "J. Agric. Food Chem."xsd:string |