| http://purl.uniprot.org/citations/28475895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28475895 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysregulated rRNA synthesis by RNA polymerase I (Pol I) is associated with uncontrolled cell proliferation. Here, we report a box H/ACA small nucleolar RNA (snoRNA)-ended long noncoding RNA (lncRNA) that enhances pre-rRNA transcription (SLERT). SLERT requires box H/ACA snoRNAs at both ends for its biogenesis and translocation to the nucleolus. Deletion of SLERT impairs pre-rRNA transcription and rRNA production, leading to decreased tumorigenesis. Mechanistically, SLERT interacts with DEAD-box RNA helicase DDX21 via a 143-nt non-snoRNA sequence. Super-resolution images reveal that DDX21 forms ring-shaped structures surrounding multiple Pol I complexes and suppresses pre-rRNA transcription. Binding by SLERT allosterically alters individual DDX21 molecules, loosens the DDX21 ring, and evicts DDX21 suppression on Pol I transcription. Together, our results reveal an important control of ribosome biogenesis by SLERT lncRNA and its regulatory role in DDX21 ring-shaped arrangements acting on Pol I complexes."xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2017.04.011"xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/author | "Dong R."xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/author | "Jiang S."xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/author | "Xu G."xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/author | "Guo C.J."xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/author | "Chen L.L."xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/author | "Yao R.W."xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/author | "Xing Y.H."xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/pages | "664-678.e16"xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/title | "SLERT Regulates DDX21 Rings Associated with Pol I Transcription."xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://purl.uniprot.org/core/volume | "169"xsd:string |
| http://purl.uniprot.org/citations/28475895 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28475895 |
| http://purl.uniprot.org/citations/28475895 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28475895 |
| http://purl.uniprot.org/uniprot/#_B3KMT3-mappedCitation-28475895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28475895 |
| http://purl.uniprot.org/uniprot/#_B3KRS4-mappedCitation-28475895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28475895 |
| http://purl.uniprot.org/uniprot/#_B3KM73-mappedCitation-28475895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28475895 |
| http://purl.uniprot.org/uniprot/#_B4DU42-mappedCitation-28475895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28475895 |
| http://purl.uniprot.org/uniprot/#_Q3SWU7-mappedCitation-28475895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28475895 |
| http://purl.uniprot.org/uniprot/#_Q8NI92-mappedCitation-28475895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28475895 |