| http://purl.uniprot.org/citations/28478325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28478325 | http://www.w3.org/2000/01/rdf-schema#comment | "Proper and efficient differentiation of dopaminergic (DA) neurons is essential for the cell-based dopamine replacement strategies that have become an attractive therapeutical option in Parkinson's disease, a disorder typically known for the degeneration of the nigral DA neurons. Here, we established that the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 2 (SIRT2) interacts with protein kinase B, and, via the glycogen synthase kinase 3β/β-catenin pathway, modulates the differentiation of DA neurons. Deletion of SIRT2 resulted in a decreased number of DA neurons in the substantia nigra and lower striatal fiber density in SIRT2 knock-out mice. Similarly, we found a decreased ratio of DA neurons in primary midbrain cultures treated with the SIRT2 inhibitor AK-7. Using protein kinase B and glycogen synthase kinase 3β inhibitors, we found that those molecules act downstream of SIRT2. Thus, SIRT2 acts as a novel regulator of the differentiation process of DA neurons, further supporting its potential as a therapeutic target in Parkinson's disease."xsd:string |
| http://purl.uniprot.org/citations/28478325 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neurobiolaging.2017.04.001"xsd:string |
| http://purl.uniprot.org/citations/28478325 | http://purl.uniprot.org/core/author | "Gerhardt E."xsd:string |
| http://purl.uniprot.org/citations/28478325 | http://purl.uniprot.org/core/author | "Outeiro T.F."xsd:string |
| http://purl.uniprot.org/citations/28478325 | http://purl.uniprot.org/core/author | "Szego E.M."xsd:string |
| http://purl.uniprot.org/citations/28478325 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28478325 | http://purl.uniprot.org/core/name | "Neurobiol Aging"xsd:string |
| http://purl.uniprot.org/citations/28478325 | http://purl.uniprot.org/core/pages | "7-16"xsd:string |
| http://purl.uniprot.org/citations/28478325 | http://purl.uniprot.org/core/title | "Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3beta/beta-catenin pathway."xsd:string |
| http://purl.uniprot.org/citations/28478325 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/28478325 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28478325 |
| http://purl.uniprot.org/citations/28478325 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28478325 |
| http://purl.uniprot.org/uniprot/#_A0A140LHL5-mappedCitation-28478325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28478325 |
| http://purl.uniprot.org/uniprot/#_Q3UJK6-mappedCitation-28478325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28478325 |
| http://purl.uniprot.org/uniprot/#_Q8VDQ8-mappedCitation-28478325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28478325 |
| http://purl.uniprot.org/uniprot/Q8VDQ8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28478325 |
| http://purl.uniprot.org/uniprot/A0A140LHL5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28478325 |
| http://purl.uniprot.org/uniprot/Q3UJK6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28478325 |