| http://purl.uniprot.org/citations/28485208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28485208 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular matrix (ECM) stiffness regulates cell differentiation, survival, and migration. Our previous study has shown that the interaction of the focal adhesion protein vinculin with vinexin α plays a critical role in sensing ECM stiffness and regulating stiffness-dependent cell migration. However, the mechanism how vinculin-vinexin α interaction affects stiffness-dependent cell migration is unclear. Lipid rafts are membrane microdomains that are known to affect ECM-induced signals and cell behaviors. Here, we show that vinculin and vinexin α can localize to lipid rafts. Cell-ECM adhesion, intracellular tension, and a rigid ECM promote vinculin distribution to lipid rafts. The disruption of lipid rafts with Methyl-β-cyclodextrin impaired the ECM stiffness-mediated regulation of vinculin behavior and rapid cell migration on rigid ECM. These results indicate that lipid rafts play an important role in ECM-stiffness regulation of cell migration via vinculin."xsd:string |
| http://purl.uniprot.org/citations/28485208 | http://purl.org/dc/terms/identifier | "doi:10.1080/09168451.2017.1289074"xsd:string |
| http://purl.uniprot.org/citations/28485208 | http://purl.uniprot.org/core/author | "Matsuo M."xsd:string |
| http://purl.uniprot.org/citations/28485208 | http://purl.uniprot.org/core/author | "Ueda K."xsd:string |
| http://purl.uniprot.org/citations/28485208 | http://purl.uniprot.org/core/author | "Yamashita H."xsd:string |
| http://purl.uniprot.org/citations/28485208 | http://purl.uniprot.org/core/author | "Kioka N."xsd:string |
| http://purl.uniprot.org/citations/28485208 | http://purl.uniprot.org/core/author | "Nagasato A.I."xsd:string |
| http://purl.uniprot.org/citations/28485208 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28485208 | http://purl.uniprot.org/core/name | "Biosci Biotechnol Biochem"xsd:string |
| http://purl.uniprot.org/citations/28485208 | http://purl.uniprot.org/core/pages | "1136-1147"xsd:string |
| http://purl.uniprot.org/citations/28485208 | http://purl.uniprot.org/core/title | "The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix."xsd:string |
| http://purl.uniprot.org/citations/28485208 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/28485208 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28485208 |
| http://purl.uniprot.org/citations/28485208 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28485208 |
| http://purl.uniprot.org/uniprot/#_Q64727-mappedCitation-28485208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28485208 |
| http://purl.uniprot.org/uniprot/#_Q8K0M3-mappedCitation-28485208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28485208 |
| http://purl.uniprot.org/uniprot/#_Q9ESQ3-mappedCitation-28485208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28485208 |
| http://purl.uniprot.org/uniprot/#_Q9R1Z8-mappedCitation-28485208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28485208 |
| http://purl.uniprot.org/uniprot/Q64727 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28485208 |
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| http://purl.uniprot.org/uniprot/Q9ESQ3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28485208 |