| http://purl.uniprot.org/citations/28487473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28487473 | http://www.w3.org/2000/01/rdf-schema#comment | "We have been investigating transcriptional regulation of the BMAL1 gene, a critical component of the mammalian clock system including DNA methylation. Here, a more detailed analysis of the regulation of DNA methylation of BMAL1 proceeded in RPMI8402 lymphoma cells. We found that CpG islands in the BMAL1 and the PER2 promoters were hyper- and hypomethylated, respectively and that 5-aza-2'-deoxycytidine (aza-dC) not only enhanced PER2 gene expression but also PER2 oscillation within 24 h in RPMI8402 cells. That is, such hypermethylation of CpG islands in the BMAL1 promoter restricted PER2 expression which was recovered by aza-dC within 1 day in these cells. These results suggest that the circadian clock system can be recovered through BMAL1 expression induced by aza-dC within a day. The RPIB9 promoter of RPMI8402 cells, which is a methylation hotspot in lymphoblastic leukemia, was also hypermethylated and aza-dC gradually recovered RPIB9 expression in 3 days. In addition, methylation-specific PCR revealed a different degree of aza-dC-induced methylation release between BMAL1 and RPIB9 These results suggest that the aza-dC-induced recovery of gene expression from DNA methylation is dependent on a gene, for example the rapid response to demethylation by the circadian system, and thus, is of importance to clinical strategies for treating cancer."xsd:string |
| http://purl.uniprot.org/citations/28487473 | http://purl.org/dc/terms/identifier | "doi:10.1042/bsr20170053"xsd:string |
| http://purl.uniprot.org/citations/28487473 | http://purl.uniprot.org/core/author | "Tomita T."xsd:string |
| http://purl.uniprot.org/citations/28487473 | http://purl.uniprot.org/core/author | "Onishi Y."xsd:string |
| http://purl.uniprot.org/citations/28487473 | http://purl.uniprot.org/core/author | "Kurita R."xsd:string |
| http://purl.uniprot.org/citations/28487473 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28487473 | http://purl.uniprot.org/core/name | "Biosci Rep"xsd:string |
| http://purl.uniprot.org/citations/28487473 | http://purl.uniprot.org/core/pages | "BSR20170053"xsd:string |
| http://purl.uniprot.org/citations/28487473 | http://purl.uniprot.org/core/title | "Epigenetic regulation of the circadian clock: role of 5-aza-2'-deoxycytidine."xsd:string |
| http://purl.uniprot.org/citations/28487473 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/28487473 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28487473 |
| http://purl.uniprot.org/citations/28487473 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28487473 |
| http://purl.uniprot.org/uniprot/#_A0A140VKD3-mappedCitation-28487473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28487473 |
| http://purl.uniprot.org/uniprot/#_A0A669KBF4-mappedCitation-28487473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28487473 |
| http://purl.uniprot.org/uniprot/#_B2RCL8-mappedCitation-28487473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28487473 |
| http://purl.uniprot.org/uniprot/#_O00327-mappedCitation-28487473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28487473 |
| http://purl.uniprot.org/uniprot/A0A140VKD3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28487473 |
| http://purl.uniprot.org/uniprot/O00327 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28487473 |
| http://purl.uniprot.org/uniprot/A0A669KBF4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28487473 |
| http://purl.uniprot.org/uniprot/B2RCL8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28487473 |