| http://purl.uniprot.org/citations/28487484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28487484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28487484 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) play critical roles in a broad variety of biological processes by inhibiting translation initiation and by destabilizing target mRNAs. The CCR4-NOT complex effects miRNA-mediated silencing, at least in part through interactions with 4E-T (eIF4E transporter) protein, but the precise mechanism is unknown. Here we show that the cap-binding eIF4E-homologous protein 4EHP is an integral component of the miRNA-mediated silencing machinery. We demonstrate that the cap-binding activity of 4EHP contributes to the translational silencing by miRNAs through the CCR4-NOT complex. Our results show that 4EHP competes with eIF4E for binding to 4E-T, and this interaction increases the affinity of 4EHP for the cap. We propose a model wherein the 4E-T/4EHP interaction engenders a closed-loop mRNA conformation that blocks translational initiation of miRNA targets."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1701488114"xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1701488114"xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Gingras A.C."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Gingras A.C."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Alain T."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Alain T."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Attig J."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Attig J."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Chapat C."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Chapat C."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Duchaine T.F."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Duchaine T.F."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Fabian M.R."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Fabian M.R."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Gelbart I.A."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Gelbart I.A."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Gkogkas C.G."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Gkogkas C.G."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Hesketh G.G."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Hesketh G.G."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Jafarnejad S.M."xsd:string |
| http://purl.uniprot.org/citations/28487484 | http://purl.uniprot.org/core/author | "Jafarnejad S.M."xsd:string |