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| http://purl.uniprot.org/citations/28489600 | http://www.w3.org/2000/01/rdf-schema#comment | "The association between metabolic diseases and the risk of developing cancer is emerging. However, the impact of long pentraxin-3 (PTX3) on dyslipidemia-associated tumor metastasis remains unknown. In this study, we found that oleate induced PTX3 expression and secretion through the activation of Akt/NF-κB pathway in head and neck squamous cell carcinomas (HNSCCs). The activation of NF-κB was essential for the oleate-induced stabilization of PTX3 mRNA. In addition, both the depletion of PTX3 and the inhibition of NF-κB significantly inhibited oleate-induced tumor cell migration and invasion. The enhancement of binding between tumor and endothelial cells was observed in oleate-treated cells but not in the depletion and neutralization of PTX3 with siPTX3 and anti-PTX3 antibodies, respectively. The levels of oleate-induced epithelial-mesenchymal transition (EMT) markers, such as vimentin and MMP-3, were significantly reduced in PTX3-depleted cells. Knocking down vimentin also repressed oleate-induced HNSCC invasion. Furthermore, the depletion of PTX3 blocked the oleate-primed metastatic seeding of tumor cells in the lungs. These results demonstrate that oleate enhances HNSCC metastasis through the PTX3/vimentin signaling axes. The inhibition of PTX3 could be a potential strategy for the treatment of dyslipidemia-mediated HNSCC metastasis."xsd:string |
| http://purl.uniprot.org/citations/28489600 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.17326"xsd:string |
| http://purl.uniprot.org/citations/28489600 | http://purl.uniprot.org/core/author | "Chen B.K."xsd:string |
| http://purl.uniprot.org/citations/28489600 | http://purl.uniprot.org/core/author | "Chan S.H."xsd:string |
| http://purl.uniprot.org/citations/28489600 | http://purl.uniprot.org/core/author | "Shen C.J."xsd:string |
| http://purl.uniprot.org/citations/28489600 | http://purl.uniprot.org/core/author | "Liao Y.H."xsd:string |
| http://purl.uniprot.org/citations/28489600 | http://purl.uniprot.org/core/author | "Tsai J.P."xsd:string |
| http://purl.uniprot.org/citations/28489600 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28489600 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/28489600 | http://purl.uniprot.org/core/pages | "41364-41378"xsd:string |
| http://purl.uniprot.org/citations/28489600 | http://purl.uniprot.org/core/title | "Oleate-induced PTX3 promotes head and neck squamous cell carcinoma metastasis through the up-regulation of vimentin."xsd:string |
| http://purl.uniprot.org/citations/28489600 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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