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| http://purl.uniprot.org/citations/28495837 | http://www.w3.org/2000/01/rdf-schema#comment | "Kinetochores mediate chromosome congression by either sliding along the lattice of spindle microtubules or forming end-on attachments to their depolymerizing plus-ends. By following the fates of individual kinetochores as they congress in live cells, we reveal that the Ska complex is required for a distinct substep of the depolymerization-coupled pulling mechanism. Ska depletion increases the frequency of naturally occurring, force-dependent P kinetochore detachment events, while being dispensable for the initial biorientation and movement of chromosomes. In unperturbed cells, these release events are followed by reattachment and successful congression, whereas in Ska-depleted cells, detached kinetochores remain in a futile reattachment/detachment cycle that prevents congression. We further find that Ska is progressively loaded onto bioriented kinetochore pairs as they congress. We thus propose a model in which kinetochores mature through Ska complex recruitment and that this is required for improved load-bearing capacity and silencing of the spindle assembly checkpoint."xsd:string |
| http://purl.uniprot.org/citations/28495837 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201607096"xsd:string |
| http://purl.uniprot.org/citations/28495837 | http://purl.uniprot.org/core/author | "Royle S.J."xsd:string |
| http://purl.uniprot.org/citations/28495837 | http://purl.uniprot.org/core/author | "McAinsh A.D."xsd:string |
| http://purl.uniprot.org/citations/28495837 | http://purl.uniprot.org/core/author | "Auckland P."xsd:string |
| http://purl.uniprot.org/citations/28495837 | http://purl.uniprot.org/core/author | "Clarke N.I."xsd:string |
| http://purl.uniprot.org/citations/28495837 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28495837 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/28495837 | http://purl.uniprot.org/core/pages | "1623-1639"xsd:string |
| http://purl.uniprot.org/citations/28495837 | http://purl.uniprot.org/core/title | "Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment."xsd:string |
| http://purl.uniprot.org/citations/28495837 | http://purl.uniprot.org/core/volume | "216"xsd:string |
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