| http://purl.uniprot.org/citations/28499756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28499756 | http://www.w3.org/2000/01/rdf-schema#comment | "Cutaneous melanoma (CM) is the most lethal skin cancer. The Wnt pathway has an impact on development, invasion, and metastasis of CM, thus likely affecting CM prognosis. Using data from a published genome-wide association study from The University of Texas MD Anderson Cancer Center, we assessed the associations of 19,830 common single-nucleotide polymorphisms (SNPs) in 151 Wnt pathway autosomal genes with CM-specific survival and then validated significant SNPs in another genome-wide association study from Harvard University. In the single-locus analysis, 1,855 SNPs were significantly associated with CM-specific survival at P < 0.05, of which 547 SNPs were still considered noteworthy after the correction by the false-positive report probability. In the replication, two SNPs remained significantly associated with CM-specific survival after multiple comparison correction. By performing functional prediction and stepwise selection, we identified two independent SNPs (i.e., WNT2B rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 × 10-5) and 0.61 (0.46-0.80, 3.12×10-4), respectively. Collectively, these variants in the Wnt pathway genes may be biomarkers for outcomes of patients with CM, if validated by larger studies."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jid.2017.04.023"xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/author | "Han J."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/author | "Han P."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/author | "Zhu D."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/author | "Shi Q."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/author | "Wu W."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/author | "Wei Q."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/author | "Lee J.E."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/author | "Amos C.I."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/author | "Fang S."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/pages | "1749-1756"xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/title | "Genetic Variants in WNT2B and BTRC Predict Melanoma Survival."xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://purl.uniprot.org/core/volume | "137"xsd:string |
| http://purl.uniprot.org/citations/28499756 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28499756 |
| http://purl.uniprot.org/citations/28499756 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28499756 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4Q5-mappedCitation-28499756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28499756 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z507-mappedCitation-28499756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28499756 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4P6-mappedCitation-28499756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28499756 |