| http://purl.uniprot.org/citations/28512129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28512129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28512129 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein O-mannosylation is found in yeast and metazoans, and a family of conserved orthologous protein O-mannosyltransferases is believed to initiate this important post-translational modification. We recently discovered that the cadherin superfamily carries O-linked mannose (O-Man) glycans at highly conserved residues in specific extracellular cadherin domains, and it was suggested that the function of E-cadherin was dependent on the O-Man glycans. Deficiencies in enzymes catalyzing O-Man biosynthesis, including the two human protein O-mannosyltransferases, POMT1 and POMT2, underlie a subgroup of congenital muscular dystrophies designated α-dystroglycanopathies, because deficient O-Man glycosylation of α-dystroglycan disrupts laminin interaction with α-dystroglycan and the extracellular matrix. To explore the functions of O-Man glycans on cadherins and protocadherins, we used a combinatorial gene-editing strategy in multiple cell lines to evaluate the role of the two POMTs initiating O-Man glycosylation and the major enzyme elongating O-Man glycans, the protein O-mannose β-1,2-N-acetylglucosaminyltransferase, POMGnT1. Surprisingly, O-mannosylation of cadherins and protocadherins does not require POMT1 and/or POMT2 in contrast to α-dystroglycan, and moreover, the O-Man glycans on cadherins are not elongated. Thus, the classical and evolutionarily conserved POMT O-mannosylation pathway is essentially dedicated to α-dystroglycan and a few other proteins, whereas a novel O-mannosylation process in mammalian cells is predicted to serve the large cadherin superfamily and other proteins."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m117.794487"xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m117.794487"xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Honig B."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Honig B."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Halim A."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Halim A."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Shapiro L."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Shapiro L."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Clausen H."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Clausen H."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Narimatsu Y."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Narimatsu Y."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Vakhrushev S.Y."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Vakhrushev S.Y."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Joshi H.J."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Joshi H.J."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Brasch J."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Brasch J."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Harrison O.J."xsd:string |
| http://purl.uniprot.org/citations/28512129 | http://purl.uniprot.org/core/author | "Harrison O.J."xsd:string |