| http://purl.uniprot.org/citations/28513074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28513074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28513074 | http://www.w3.org/2000/01/rdf-schema#comment | "Δ-Myrtoxin-Mp1a (Mp1a), a 49-residue heterodimeric peptide from the venom of Myrmecia pilosula, comprises a 26-mer A chain and a 23-mer B chain connected by two disulfide bonds in an antiparallel arrangement. Combination of the individual synthetic chains through aerial oxidation remarkably resulted in the self-assembly of Mp1a as a homogenous product without the need for directed disulfide-bond formation. NMR analysis revealed a well-defined, unique structure containing an antiparallel α-helix pair. Dual polarization interferometry (DPI) analysis showed strong interaction with supported lipid bilayers and insertion within the bilayers. Mp1a caused non-specific Ca2+ influx in SH-SY5Y cells with a half maximal effective concentration (EC50 ) of 4.3 μm. Mp1a also displayed broad-spectrum antimicrobial activity, with the highest potency against Gram-negative Acinetobacter baumannii (MIC 25 nm). Intraplantar injection (10 μm) in mice elicited spontaneous pain and mechanical allodynia. Single- and two-chain mimetics of Mp1a revealed functional selectivity."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.org/dc/terms/identifier | "doi:10.1002/anie.201703360"xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.org/dc/terms/identifier | "doi:10.1002/anie.201703360"xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Alewood P.F."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Alewood P.F."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Vetter I."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Vetter I."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Dekan Z."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Dekan Z."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Deuis J.R."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Deuis J.R."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Lee T.H."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Lee T.H."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Aguilar M.I."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Aguilar M.I."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Baldo B.A."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Baldo B.A."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Alewood D."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Alewood D."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Cooper M.A."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Cooper M.A."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Amado M."xsd:string |
| http://purl.uniprot.org/citations/28513074 | http://purl.uniprot.org/core/author | "Amado M."xsd:string |