| http://purl.uniprot.org/citations/28514806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28514806 | http://www.w3.org/2000/01/rdf-schema#comment | "Epicardial adipose tissue (EAT) is an easily measurable visceral fat of the heart with unique anatomy, functionality, and transcriptome. EAT can serve as a therapeutic target for pharmaceutical agents targeting the fat. Glucagon-like peptide-1 (GLP-1) and GLP-2 analogues are newer drugs showing beneficial cardiovascular and metabolic effects. Whether EAT expresses GLP-1 and 2 receptors (GLP-1R and GLP-2R) is unknown. RNA-seq analysis and quantitative real-time polymerase chain reaction (qRT-PCR) were performed to evaluate the presence of GLP-1R and GLP-2R in EAT and subcutaneous fat (SAT) obtained from 8 subjects with coronary artery disease and type 2 diabetes mellitus undergoing elective cardiac surgery. Immunofluorescence was also performed on EAT and SAT samples using Mab3f52 against GLP-1R. Our RNA-sequencing (RNA-seq) analysis showed that EAT expresses both GLP-1R and GLP-2R genes. qRT-PCR analysis confirmed that GLP-1R expression was low but detected by 2 different sets of intron-spanning primers. GLP-2R expression was detected in all patients and was found to be 5-fold higher than GLP-1R. The combination of accurately spliced reads from RNA-seq and successful amplification using intron-spanning primers indicates that both GLP-1R and GLP-2R are expressed in EAT. Immunofluorescence clearly showed that GLP-1R is present and more abundant in EAT than SAT. This is the first time that human EAT is found to express both GLP-1R and GLP-2R genes. Pharmacologically targeting EAT may induce beneficial cardiovascular and metabolic effects."xsd:string |
| http://purl.uniprot.org/citations/28514806 | http://purl.org/dc/terms/identifier | "doi:10.1055/s-0043-109563"xsd:string |
| http://purl.uniprot.org/citations/28514806 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/28514806 | http://purl.uniprot.org/core/author | "Camarena V."xsd:string |
| http://purl.uniprot.org/citations/28514806 | http://purl.uniprot.org/core/author | "Sant D.W."xsd:string |
| http://purl.uniprot.org/citations/28514806 | http://purl.uniprot.org/core/author | "Iacobellis G."xsd:string |
| http://purl.uniprot.org/citations/28514806 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28514806 | http://purl.uniprot.org/core/name | "Horm Metab Res"xsd:string |
| http://purl.uniprot.org/citations/28514806 | http://purl.uniprot.org/core/pages | "625-630"xsd:string |
| http://purl.uniprot.org/citations/28514806 | http://purl.uniprot.org/core/title | "Human Epicardial Fat Expresses Glucagon-Like Peptide 1 and 2 Receptors Genes."xsd:string |
| http://purl.uniprot.org/citations/28514806 | http://purl.uniprot.org/core/volume | "49"xsd:string |
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