| http://purl.uniprot.org/citations/28515147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28515147 | http://www.w3.org/2000/01/rdf-schema#comment | "Prostate cancer does not appear to respond to immune checkpoint therapies where T-cell infiltration may be a key limiting factor. Here, we report evidence that ablating the growth regulatory kinase Erk5 can increase T-cell infiltration in an established Pten-deficient mouse model of human prostate cancer. Mice that were doubly mutant in prostate tissue for Pten and Erk5 (prostate DKO) exhibited a markedly increased median survival with reduced tumor size and proliferation compared with control Pten-mutant mice, the latter of which exhibited increased Erk5 mRNA expression. A comparative transcriptomic analysis revealed upregulation in prostate DKO mice of the chemokines Ccl5 and Cxcl10, two potent chemoattractants for T lymphocytes. Consistent with this effect, we observed a relative increase in a predominantly CD4+ T-cell infiltrate in the prostate epithelial and stroma of tumors from DKO mice. Collectively, our results offer a preclinical proof of concept for ERK5 as a target to enhance T-cell infiltrates in prostate cancer, with possible implications for leveraging immune therapy in this disease. Cancer Res; 77(12); 3158-68. ©2017 AACR."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-16-2565"xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/author | "Patel R."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/author | "Ahmad I."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/author | "Leung H.Y."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/author | "Welsh M."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/author | "Loveridge C.J."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/author | "Tan E.H."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/author | "Sansom O."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/author | "Blyth K."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/author | "Nixon C."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/author | "Galbraith J."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/author | "Mui E.J."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/author | "Hedley A."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/pages | "3158-3168"xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/title | "Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten-Deficient Mouse Model of Prostate Carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/28515147 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28515147 |
| http://purl.uniprot.org/citations/28515147 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28515147 |
| http://purl.uniprot.org/uniprot/#_A0A024QYR9-mappedCitation-28515147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28515147 |
| http://purl.uniprot.org/uniprot/#_A0A6G7SF19-mappedCitation-28515147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28515147 |
| http://purl.uniprot.org/uniprot/#_A0A1V0DNR6-mappedCitation-28515147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28515147 |