| http://purl.uniprot.org/citations/28521215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28521215 | http://www.w3.org/2000/01/rdf-schema#comment | "The binding of the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer ((gp120/gp41)3) to the receptors CD4 and CCR5 triggers virus entry into host cells. To identify Env regions that respond to CCR5 binding, HIV-1 was serially passaged on a CD4-positive canine cell line expressing progressively lower levels of CCR5. HIV-1 replication was observed in cells expressing ~1300 CCR5 molecules/cell. Env changes that conferred this low-CCR5 replication phenotype were located outside of the known CCR5-binding region of the gp120 Env subunit and did not apparently increase CCR5 binding affinity. The adaptation-associated changes, located in the gp120 α1 helix and in the gp41 HR1 heptad repeat and membrane-proximal external region (MPER), enhanced HIV-1 replication in cells at all levels of CCR5 expression. The adapted Envs exhibited a greater propensity to undergo conformational changes, as evidenced by increased exposure of conserved regions near the CD4- and CCR5-binding sites."xsd:string |
| http://purl.uniprot.org/citations/28521215 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2017.04.033"xsd:string |
| http://purl.uniprot.org/citations/28521215 | http://purl.uniprot.org/core/author | "Sodroski J."xsd:string |
| http://purl.uniprot.org/citations/28521215 | http://purl.uniprot.org/core/author | "Pacheco B."xsd:string |
| http://purl.uniprot.org/citations/28521215 | http://purl.uniprot.org/core/author | "Espy N."xsd:string |
| http://purl.uniprot.org/citations/28521215 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28521215 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/28521215 | http://purl.uniprot.org/core/pages | "90-107"xsd:string |
| http://purl.uniprot.org/citations/28521215 | http://purl.uniprot.org/core/title | "Adaptation of HIV-1 to cells with low expression of the CCR5 coreceptor."xsd:string |
| http://purl.uniprot.org/citations/28521215 | http://purl.uniprot.org/core/volume | "508"xsd:string |
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