| http://purl.uniprot.org/citations/28528450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28528450 | http://www.w3.org/2000/01/rdf-schema#comment | "PurposeCyclin D1 has a central role in cell cycle control and is an important component of estrogen regulation of cell cycle progression. We have previously shown that high cyclin D expression is related to aggressive features of ER-positive but not ER-negative breast cancer. The aims of the present study were to validate this differential ER-related effect and furthermore explore the relationship between cyclin D overexpression and CCND1 gene amplification status in a node-negative breast cancer case-control study.MethodsImmunohistochemical nuclear expression of cyclin D1 (n = 364) and amplification of the gene CCND1 by fluorescent in situ hybridization (n = 255) was performed on tissue microarray sections from patients with T1-2N0M0 breast cancer. Patients given adjuvant chemotherapy were excluded. The primary event was defined as breast cancer death. Breast cancer-specific survival was analyzed in univariate and multivariable models using conditional logistic regression.ResultsExpression of cyclin D1 above the median (61.7%) in ER breast cancer was associated with an increased risk for breast cancer death (OR 3.2 95% CI 1.5-6.8) also when adjusted for tumor size and grade (OR 3.1). No significant prognostic impact of cyclin D1 expression was found among ER-negative cases. Cyclin D1 overexpression was significantly associated to high expression of the proliferation markers cyclins A (ρ 0.19, p = 0.006) and B (ρ 0.18, p = 0.003) in ER-positive tumors, but not in ER-negative cases. There was a significant association between CCND1 amplification and cyclin D1 expression (p = 0.003), but CCND1 amplification was not statistically significantly prognostic (HR 1.4, 95% CI 0.4-4.4).ConclusionWe confirmed our previous observation that high cyclin D1 expression is associated to high proliferation and a threefold higher risk of death from breast cancer in ER-positive breast cancer."xsd:string |
| http://purl.uniprot.org/citations/28528450 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10549-017-4294-5"xsd:string |
| http://purl.uniprot.org/citations/28528450 | http://purl.uniprot.org/core/author | "Blomqvist C."xsd:string |
| http://purl.uniprot.org/citations/28528450 | http://purl.uniprot.org/core/author | "Jirstrom K."xsd:string |
| http://purl.uniprot.org/citations/28528450 | http://purl.uniprot.org/core/author | "Ahlin C."xsd:string |
| http://purl.uniprot.org/citations/28528450 | http://purl.uniprot.org/core/author | "Embretsen-Varro E."xsd:string |
| http://purl.uniprot.org/citations/28528450 | http://purl.uniprot.org/core/author | "Fjallskog M.-"xsd:string |
| http://purl.uniprot.org/citations/28528450 | http://purl.uniprot.org/core/author | "Lundgren C."xsd:string |
| http://purl.uniprot.org/citations/28528450 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28528450 | http://purl.uniprot.org/core/name | "Breast Cancer Res Treat"xsd:string |
| http://purl.uniprot.org/citations/28528450 | http://purl.uniprot.org/core/pages | "667-678"xsd:string |
| http://purl.uniprot.org/citations/28528450 | http://purl.uniprot.org/core/title | "High expression of cyclin D1 is associated to high proliferation rate and increased risk of mortality in women with ER-positive but not in ER-negative breast cancers."xsd:string |
| http://purl.uniprot.org/citations/28528450 | http://purl.uniprot.org/core/volume | "164"xsd:string |
| http://purl.uniprot.org/citations/28528450 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28528450 |
| http://purl.uniprot.org/citations/28528450 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28528450 |
| http://purl.uniprot.org/uniprot/#_B4DR06-mappedCitation-28528450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28528450 |
| http://purl.uniprot.org/uniprot/#_Q14092-mappedCitation-28528450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28528450 |
| http://purl.uniprot.org/uniprot/#_P24385-mappedCitation-28528450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28528450 |
| http://purl.uniprot.org/uniprot/#_Q5MGB2-mappedCitation-28528450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28528450 |
| http://purl.uniprot.org/uniprot/#_Q6FI00-mappedCitation-28528450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28528450 |
| http://purl.uniprot.org/uniprot/Q14092 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28528450 |
| http://purl.uniprot.org/uniprot/P24385 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28528450 |
| http://purl.uniprot.org/uniprot/Q6FI00 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28528450 |
| http://purl.uniprot.org/uniprot/B4DR06 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28528450 |