| http://purl.uniprot.org/citations/28529954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28529954 | http://www.w3.org/2000/01/rdf-schema#comment | "Accounting for high mortality and morbidity rates, intracerebral hemorrhage (ICH) remains one of the most detrimental stroke subtypes lacking a specific therapy. Neuroinflammation contributes to ICH-induced brain injury and is associated with unfavorable outcomes. This study aimed to evaluate whether α7 nicotinic acetylcholine receptor (α7nAChR) stimulation ameliorates neuroinflammation after ICH. Male CD-1 mice and Sprague-Dawley were subjected to intracerebral injection of autologous blood or bacterial collagenase. ICH animals received either α7nAChR agonist PHA-543613 alone or combined with α7nAChR antagonist methyllycaconitine (MLA) or Janus kinase 2 (JAK2) antagonist AG490. Neurobehavioral deficits were evaluated at 24 hours, 72 hours, and 10 weeks after ICH induction. Perihematomal expressions of JAK2, signal transducer and activator of transcription 3 (STAT3), tumor necrosis factor-α (TNF-α), and myeloperoxidase (MPO) were quantified via Western blot. Histologic volumetric analysis of brain tissues was conducted after 10 weeks following ICH induction. PHA-543613 improved short-term neurobehavioral (sensorimotor) deficits and increased activated perihematomal JAK2 and STAT3 expressions while decreasing TNF-α and MPO expressions after ICH. MLA reversed these treatment effects. PHA-543613 also improved long-term neurobehavioral (sensorimotor, learning, and memory) deficits and ameliorated brain atrophy after ICH. These treatment effects were reduced by AG490. α7nAChR stimulation reduced neuroinflammation via activation of the JAK2-STAT3 pathway, thereby ameliorating the short- and long-term sequelae after ICH."xsd:string |
| http://purl.uniprot.org/citations/28529954 | http://purl.org/dc/terms/identifier | "doi:10.1155/2017/8134653"xsd:string |
| http://purl.uniprot.org/citations/28529954 | http://purl.uniprot.org/core/author | "Zhang J.H."xsd:string |
| http://purl.uniprot.org/citations/28529954 | http://purl.uniprot.org/core/author | "McBride D."xsd:string |
| http://purl.uniprot.org/citations/28529954 | http://purl.uniprot.org/core/author | "Lekic T."xsd:string |
| http://purl.uniprot.org/citations/28529954 | http://purl.uniprot.org/core/author | "Flores J.J."xsd:string |
| http://purl.uniprot.org/citations/28529954 | http://purl.uniprot.org/core/author | "Rolland W.B."xsd:string |
| http://purl.uniprot.org/citations/28529954 | http://purl.uniprot.org/core/author | "Krafft P.R."xsd:string |
| http://purl.uniprot.org/citations/28529954 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28529954 | http://purl.uniprot.org/core/name | "Biomed Res Int"xsd:string |
| http://purl.uniprot.org/citations/28529954 | http://purl.uniprot.org/core/pages | "8134653"xsd:string |
| http://purl.uniprot.org/citations/28529954 | http://purl.uniprot.org/core/title | "pii>alphapi/i>7 Nicotinic Acetylcholine Receptor Stimulation Attenuates Neuroinflammation through JAK2-STAT3 Activation in Murine Models of Intracerebral Hemorrhage."xsd:string |
| http://purl.uniprot.org/citations/28529954 | http://purl.uniprot.org/core/volume | "2017"xsd:string |
| http://purl.uniprot.org/citations/28529954 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28529954 |
| http://purl.uniprot.org/citations/28529954 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28529954 |
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