| http://purl.uniprot.org/citations/28531251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28531251 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca2+ signals are transient, hence, upon a stimulus-induced increase in cytosolic Ca2+ concentration, cells have to re-establish resting Ca2+ levels. Ca2+ extrusion is operated by a wealth of transporters, such as Ca2+ pumps and Ca2+/H+ antiporters, which often require a rise in Ca2+ concentration to be activated. Here, we report a regulatory fine-tuning mechanism of the Arabidopsis thaliana plasma membrane-localized Ca2+-ATPase isoform ACA8 that is mediated by calcineurin B-like protein (CBL) and CBL-interacting protein kinase (CIPK) complexes. We show that two CIPKs (CIPK9 and CIPK14) are able to interact with ACA8 in vivo and phosphorylate it in vitro. Transient co-overexpression of ACA8 with CIPK9 and the plasma membrane Ca2+ sensor CBL1 in tobacco leaf cells influences nuclear Ca2+ dynamics, specifically reducing the height of the second peak of the wound-induced Ca2+ transient. Stimulus-induced Ca2+ transients in mature leaves and seedlings of an aca8 T-DNA insertion line exhibit altered dynamics when compared with the wild type. Altogether our results identify ACA8 as a prominent in vivo regulator of cellular Ca2+ dynamics and reveal the existence of a Ca2+-dependent CBL-CIPK-mediated regulatory feedback mechanism, which crucially functions in the termination of Ca2+ signals."xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.org/dc/terms/identifier | "doi:10.1093/jxb/erx162"xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/author | "Hashimoto K."xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/author | "Bonza M.C."xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/author | "De Michelis M.I."xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/author | "Luoni L."xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/author | "Costa A."xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/author | "Kudla J."xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/author | "Giacometti S."xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/author | "Koster P."xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/author | "Marrano C.A."xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/name | "J Exp Bot"xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/pages | "3215-3230"xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/title | "Ca2+-dependent phosphoregulation of the plasma membrane Ca2+-ATPase ACA8 modulates stimulus-induced calcium signatures."xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/28531251 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28531251 |
| http://purl.uniprot.org/citations/28531251 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28531251 |
| http://purl.uniprot.org/uniprot/#_A0A1P8B7Z8-mappedCitation-28531251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28531251 |
| http://purl.uniprot.org/uniprot/#_A0A384L942-mappedCitation-28531251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28531251 |
| http://purl.uniprot.org/uniprot/#_A0A1P8BGF7-mappedCitation-28531251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28531251 |
| http://purl.uniprot.org/uniprot/#_F4JP88-mappedCitation-28531251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28531251 |
| http://purl.uniprot.org/uniprot/#_Q0WV19-mappedCitation-28531251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28531251 |
| http://purl.uniprot.org/uniprot/#_O81445-mappedCitation-28531251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28531251 |