| http://purl.uniprot.org/citations/28535372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28535372 | http://www.w3.org/2000/01/rdf-schema#comment | "Intimate communication between neural and vascular cells is critical for normal brain development and function. Germinal matrix (GM), a key primordium for the brain reward circuitry, is unique among brain regions for its distinct pace of angiogenesis and selective vulnerability to hemorrhage during development. A major neonatal condition, GM hemorrhage can lead to cerebral palsy, hydrocephalus, and mental retardation. Here we identify a brain-region-specific neural progenitor-based signaling pathway dedicated to regulating GM vessel development. This pathway consists of cell-surface sphingosine-1-phosphate receptors, an intracellular cascade including Gα co-factor Ric8a and p38 MAPK, and target gene integrin β8, which in turn regulates vascular TGF-β signaling. These findings provide insights into region-specific specialization of neurovascular communication, with special implications for deciphering potent early-life endocrine, as well as potential gut microbiota impacts on brain reward circuitry. They also identify tissue-specific molecular targets for GM hemorrhage intervention."xsd:string |
| http://purl.uniprot.org/citations/28535372 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2017.04.014"xsd:string |
| http://purl.uniprot.org/citations/28535372 | http://purl.uniprot.org/core/author | "Ma S."xsd:string |
| http://purl.uniprot.org/citations/28535372 | http://purl.uniprot.org/core/author | "Huang Z."xsd:string |
| http://purl.uniprot.org/citations/28535372 | http://purl.uniprot.org/core/author | "Santhosh D."xsd:string |
| http://purl.uniprot.org/citations/28535372 | http://purl.uniprot.org/core/author | "Kumar T P."xsd:string |
| http://purl.uniprot.org/citations/28535372 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28535372 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/28535372 | http://purl.uniprot.org/core/pages | "366-381.e4"xsd:string |
| http://purl.uniprot.org/citations/28535372 | http://purl.uniprot.org/core/title | "A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/28535372 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/28535372 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28535372 |
| http://purl.uniprot.org/citations/28535372 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28535372 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E1-mappedCitation-28535372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28535372 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-28535372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28535372 |
| http://purl.uniprot.org/uniprot/#_P70677-mappedCitation-28535372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28535372 |
| http://purl.uniprot.org/uniprot/#_Q0VBD0-mappedCitation-28535372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28535372 |
| http://purl.uniprot.org/uniprot/#_A0A140LHU8-mappedCitation-28535372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28535372 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRC0-mappedCitation-28535372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28535372 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRX1-mappedCitation-28535372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28535372 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT69-mappedCitation-28535372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28535372 |
| http://purl.uniprot.org/uniprot/#_A2CG44-mappedCitation-28535372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28535372 |
| http://purl.uniprot.org/uniprot/#_A2CG45-mappedCitation-28535372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28535372 |
| http://purl.uniprot.org/uniprot/#_A0A140LIU2-mappedCitation-28535372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28535372 |